(3-甲基哌啶-4-基)氨基甲酸叔丁酯 | 866538-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: (3-甲基哌啶-4-基)氨基甲酸叔丁酯
• 中文别名: (3-甲基-4-哌啶基)氨基甲酸叔丁酯
• 英文名称: 3-methyl-4-(tert-butoxycarbonyl)aminopiperidine
• 英文别名: tert-butyl (3-methylpiperidin-4-yl)carbamate；trans-3-Methylpiperidin-4-ylcarbamic acid tert-butyl ester；trans4-t-Butyloxycarbonylamino-3-methylpiperidine；tert-butyl N-(3-methylpiperidin-4-yl)carbamate
• CAS: 866538-96-7
• 化学式: C₁₁H₂₂N₂O₂
• mdl: MFCD09701320
• 分子量: 214.308
• InChiKey: LHSNRJGZDUFKQT-UHFFFAOYSA-N

物化性质

• 密度：
  1.00

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  (3-甲基哌啶-4-基)氨基甲酸叔丁酯 在 palladium on activated charcoal 氢气 、 四丁基碘化铵 、 sodium hydride 、 碳酸氢钠 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 80.0 ℃ 、379.21 kPa 条件下， 生成 [1-(4-Benzyloxycarbonylamino-2-fluoro-phenyl)-3-methyl-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and SAR of novel oxazolidinones: Discovery of ranbezolid

  摘要：

  Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the 'piperazinyl-phenyl-oxazolidinone' core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible Gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.063
• 作为产物：
  描述：

  trans-4-t-Butyloxycarbonylamino-1-benzyl-3-methylpiperidine 以 cis-4-t-Butyloxycarbonylamino-1-benzyl-3-methylpiperidine 为溶剂， 以96%的产率得到(3-甲基哌啶-4-基)氨基甲酸叔丁酯
  参考文献：
  名称：

  Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments

  摘要：

  这项发明涉及新一代三靶向手性广谱抗菌7-取代哌啶喹啉羧酸衍生物，以及它们的光学异构体、二对映异构体或对映异构体，以及它们的药用盐、水合物、前药、多型和伪多型，以及它们的制备、组合物和用途。

  公开号：

  US06878713B2

文献信息

• [EN] ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS D'ECTONUCLÉOTIDES PYROPHOSPHATASES/PHOSPHODIESTÉRASES 1 (ENPP1) ET LEURS UTILISATIONS
  申请人：SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST

  公开号：WO2021133915A1

  公开（公告）日：2021-07-01

  Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供了外胞核苷酸焦磷酸酶/磷酸二酯酶1（ENPP1）的小分子调节剂，包括这些化合物的组合物，以及使用这些化合物和包含这些化合物的组合物的方法。
• PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE
  申请人：Tsuboike Kazunari

  公开号：US20120149902A1

  公开（公告）日：2012-06-14

  Provided is a compound represented by the Formula (I) having a HER2 inhibitory action or a pharmacologically acceptable salt thereof, wherein T 1 is a phenyl group, an indazolyl group, or a benzofuryl group, n is an integer of 0 to 3, R 1 is a hydrogen atom, a halogen atom, a C 1-4 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, or a C 1-4 alkoxy group, m is an integer of 0 to 3, R 2 is a hydroxy group or a C 1-4 alkyl group optionally substituted with one or two C 1-4 alkoxy groups, and R 3 is a hydrogen atom, a C 1-4 alkyl group, or a C 2-6 alkynyl group.

  提供的是由式（I）表示的化合物，具有HER2抑制作用或其药理学上可接受的盐， 其中T 1 是苯基、吲唑基或苯并呋喃基，n为0至3的整数，R 1 是氢原子、卤原子、C 1-4 烷基、C 2-6 烯基、C 2-6 炔基或C 1-4 烷氧基，m为0至3的整数，R 2 是羟基或一个或两个C 1-4 烷氧基可选择地取代的C 1-4 烷基，R 3 是氢原子、C 1-4 烷基或C 2-6 炔基。
• [EN] CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS<br/>[FR] COMPOSÉS CHIMIQUES UTILISÉS COMME INHIBITEURS DE LA VOIE ATF4
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2017212425A1

  公开（公告）日：2017-12-14

  The invention is directed to substituted piperidine derivatives. Specifically, the invention is directed to compounds according to Formula IIII: wherein A, B, X, Y, L1, L2, L3, R1, R2, R3, R4, R5, R6, R9, z2, z4, z5, and z6 are as defined herein, and salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and acute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

  该发明涉及替代哌啶衍生物。具体而言，该发明涉及符合以下式III的化合物：其中A、B、X、Y、L1、L2、L3、R1、R2、R3、R4、R5、R6、R9、z2、z4、z5和z6如本文所定义，并其盐。该发明的化合物是ATF4途径的抑制剂，可用于治疗癌症、癌前综合征以及与激活的未折叠蛋白应答途径相关的疾病，如阿尔茨海默病、脊髓损伤、创伤性脑损伤、缺血性中风、中风、糖尿病、帕金森病、亨廷顿病、克雅氏病及相关朊蛋白病、进行性核上性麻痹、肌萎缩侧索硬化、心肌梗死、心血管疾病、炎症、纤维化、肝脏慢性和急性疾病、肺部慢性和急性疾病、肾脏慢性和急性疾病、慢性创伤性脑病（CTE）、神经退行性疾病、痴呆、认知障碍、动脉粥样硬化、眼部疾病、心律失常、器官移植以及器官移植运输。因此，该发明进一步涉及包含该发明化合物的药物组合物。该发明还进一步涉及使用该发明化合物或包含该发明化合物的药物组合物抑制ATF4途径和治疗相关疾病的方法。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation,compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030216568A1

  公开（公告）日：2003-11-20

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗菌7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及其药学上可接受的盐、水合物、前药、多晶形和假多晶形，以及它们的制备、组成和用途。
• [EN] PYRAZOLOPYRIDINE AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE<br/>[FR] COMPOSÉS AMINE PYRAZOLOPYRIDINIQUES POUR LE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2020052738A1

  公开（公告）日：2020-03-19

  The present invention relates to compounds of formula (I), wherein R1, R2, R3,R4 and X are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

  本发明涉及式(I)的化合物，其中R1，R2，R3，R4和X如此描述，以及它们的药学上可接受的盐、对映体或二对映体，以及包括这些化合物的组合物和使用这些化合物的方法。