(3R,4R,5R,6R,7R,8R,9S,10R,13R,14R,17R)-3,4,6,7-四羟基-17-[(1S)-1-[(2R,4S)-6-羟基-4-丙-2-基四氢吡喃-2-基]乙基]-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,14,16,17-十四氢环戊烯并[a]菲-15-酮 | 137571-30-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: (3R,4R,5R,6R,7R,8R,9S,10R,13R,14R,17R)-3,4,6,7-四羟基-17-[(1S)-1-[(2R,4S)-6-羟基-4-丙-2-基四氢吡喃-2-基]乙基]-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,14,16,17-十四氢环戊烯并[a]菲-15-酮
• 中文别名: (11R)-11,17-二羟基-3,4-二甲氧基三环[12.3.1.1~2,6~]十九碳-1(18),2(19),3,5,14,16-六烯-5-基β-D-吡喃葡萄糖苷
• 英文名称: Contignasterol
• 英文别名: (3R,4R,5R,6R,7R,8R,9S,10R,13R,14R,17R)-3,4,6,7-tetrahydroxy-17-[(1S)-1-[(2R,4S)-6-hydroxy-4-propan-2-yloxan-2-yl]ethyl]-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,16,17-tetradecahydrocyclopenta[a]phenanthren-15-one
• CAS: 137571-30-3
• 化学式: C₂₉H₄₈O₇
• 分子量: 508.7
• InChiKey: IRHVLQMEQPABHG-QUZWXNHXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• OLIGONUCLEOTIDE DECOYS AND METHODS OF USE
  申请人：Jones Walter Keith

  公开号：US20090099108A1

  公开（公告）日：2009-04-16

  The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end repeated copies of a short (more than 5, 10, 15, 20, 2, 3035, 40, 45, 50, 75, 100, or more by but generally less than about 3 kb) dsDNA containing a sequence or sequences that act as transcription factor decoys. The present invention also provides for the use of the polymers for CODN/polymer complexes to a specific cell type; thus the agent can be made organ, tissue and/or cell-type specific. In another embodiment, the present invention provides for use of the CODN's in vitro or in vivo, in isolated cells or intact animals in which specific blockade of transcription factors or delivery of DNA or other biological effector is desirable. In one embodiment, this includes use as a research tool, including studies of specific genes and studies to identify specific genes regulated by the transcription factors targeted. In another embodiment, the present invention provides for using polyamides for NF-kB-specific CODN delivery in the treatment of myocardial ischemia/reperfusion and myocardial infarction, heart failure and hypertrophy, cardioprotection, stroke, neuroprotection, sepsis, arthritis, asthma, heritable inflammatory disorders, cancer, heritable immune dysfunctions, inflammatory processes, whether caused by disease or injury or infection, oxidative stress to any organ whether caused by disease, surgery or injury. The decoys may be any transcription factors, including, but not limited to, NF-kB, AP-I, ATF2, ATF3, SP 1 and others.

  本发明描述了一种使用串联双链寡核苷酸分子（CODN）作为转录因子诱饵的试剂和方法。在一种实施例中，串联体由一种短的（大于5、10、15、20、25、30、35、40、45、50、75、100或更多，但通常小于约3 kb）双链DNA的端对端重复拷贝构成，其中包含作为转录因子诱饵的一个或多个序列。本发明还提供了将聚合物用于CODN/聚合物复合物对特定细胞类型的使用；因此，该试剂可以被制成特定的器官、组织和/或细胞类型。在另一种实施例中，本发明提供了在离体或体内、在孤立的细胞或完整的动物中使用CODN的方法，其中需要特定的转录因子阻断或DNA或其他生物效应物的递送。在一种实施例中，这包括用作研究工具，包括研究特定基因和研究识别被靶向的转录因子调控的特定基因。在另一种实施例中，本发明提供了使用聚酰胺进行NF-kB特异性CODN递送，用于治疗心肌缺血/再灌注和心肌梗死、心力衰竭和肥厚、心脏保护、中风、神经保护、败血症、关节炎、哮喘、遗传性炎症性疾病、癌症、遗传性免疫功能障碍、炎症过程，无论是由疾病、手术还是损伤或感染引起的，以及对任何器官的氧化应激。诱饵可以是任何转录因子，包括但不限于NF-kB、AP-I、ATF2、ATF3、SP1等。
• Regenerative therapy
  申请人：Medizinische Universität Wien

  公开号：EP2177218A1

  公开（公告）日：2010-04-21

  The present invention relates to the use of an agent capable of enhancing the PKA-p38-CREB pathway, suppressing the Fyn-RhoA-Rock and/or PKC-alpha-MARCKS pathways or Ephrin-B3 for the manufacture of a pharmaceutical composition for the treatment of damaged myelin sheaths, characterized in that, the agent neutralizes the effect of inhibitors of the regeneration of damaged myelin sheaths by oligodendrocytes, and wherein the inhibitors are selected from myelin associated inhibitors, in particular Ephrin-B3, and inhibitors of the glial scar, in particular Sema3A, and kits suitable for the treatment of damaged myelin sheaths.

  本发明涉及一种能够增强PKA-p38-CREB通路、抑制Fyn-RhoA-Rock和/或PKC-α-MARCKS通路或Ephrin-B3的制剂在制造治疗受损髓鞘的药物组合物中的用途，其特征在于：该制剂能中和抑制少突胶质细胞再生受损髓鞘的抑制剂的作用，其中抑制剂选自髓鞘相关抑制剂，特别是 Ephrin-B3，以及胶质瘢痕抑制剂，特别是 SeMA3A，以及适用于治疗受损髓鞘的试剂盒。
• Polynucleotides and polypeptides associated with the NF-kB pathway
  申请人：——

  公开号：US20030224486A1

  公开（公告）日：2003-12-04

  The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

  本发明提供了编码 NF-kB 相关多肽、其片段和同源物的多核苷酸。还提供了载体、宿主细胞、抗体以及生产上述多肽的重组和合成方法。本发明进一步涉及将这些 NF-kB 相关多肽应用于诊断、治疗和/或预防与这些多肽相关的各种疾病和/或失调的诊断和治疗方法。本发明还涉及用于鉴定本发明多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
• SUTURES AND ANTI-SCARRING AGENTS
  申请人：Angiotech Pharmaceuticals, Inc.

  公开号：EP1978930A2

  公开（公告）日：2008-10-15
• POLYAMIDES FOR NUCLEIC ACID DELIVERY
  申请人：Reineke Theresa M.

  公开号：US20090105115A1

  公开（公告）日：2009-04-23

  The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Complexes according to the invention or portions thereof, can comprise a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells. In some embodiments, cellular delivery molecules for use in the present invention may comprise one or more polymers of the present invention, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.