(3S,4R)-哌啶-3,4-二醇 | 135501-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: (3S,4R)-哌啶-3,4-二醇
• 英文名称: 1,2,5-trideoxy-1,5-imino-D-erythritol
• 英文别名: (3R,4S)-3,4-dihydroxypiperidine；(3R,4S)-piperidine-3,4-diol；cis-Piperidin-3,4-diol；(3R,4S)-3,4-Piperidinediol
• CAS: 135501-61-0
• 化学式: C₅H₁₁NO₂
• mdl: MFCD19238003
• 分子量: 117.148
• InChiKey: IZXWMVPZODQBRB-CRCLSJGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3S,4R)-哌啶-3,4-二醇 以 乙醇 、 二氯甲烷 为溶剂， 反应 49.0h， 生成 (3R,4R)-1-tert-butoxycarbonyl-3-acetoxy-4-chloropiperidine
  参考文献：
  名称：

  2-Deoxyribose as a Rich Source of Chiral 5-Carbon Building Blocks

  摘要：

  [GRAPHICS]We have developed concise routes to a number of useful chiral 5-carbon synthetic building blocks using readily available: 0-1-methyl-2-deoxyribose as starting material. Novel transformations include the use of indium triflate to catalyze the oxidation of a methyl furanoside to the corresponding lactone with MCPBA and the Vasella-type fragmentation of a 5-iodo furanoside using chromium(II) chloride when zinc proved ineffective. In addition, 3,4-disubstitued piperidine derivatives were prepared without hydroxyl group protection via a simple reductive amination reaction.

  DOI：

  10.1021/jo0712143
• 作为产物：
  描述：

  甲基-2-脱氧-D-核糖 在 palladium on activated charcoal 吡啶 、 sodium azide 、 Amberlyst 15 、 氢气 、 四丁基碘化铵 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 20.0~80.0 ℃ 、413.7 kPa 条件下， 反应 64.0h， 生成 (3S,4R)-哌啶-3,4-二醇
  参考文献：
  名称：

  2-Deoxyribose as a Rich Source of Chiral 5-Carbon Building Blocks

  摘要：

  [GRAPHICS]We have developed concise routes to a number of useful chiral 5-carbon synthetic building blocks using readily available: 0-1-methyl-2-deoxyribose as starting material. Novel transformations include the use of indium triflate to catalyze the oxidation of a methyl furanoside to the corresponding lactone with MCPBA and the Vasella-type fragmentation of a 5-iodo furanoside using chromium(II) chloride when zinc proved ineffective. In addition, 3,4-disubstitued piperidine derivatives were prepared without hydroxyl group protection via a simple reductive amination reaction.

  DOI：

  10.1021/jo0712143

文献信息

• [EN] PYRAZOLE DERIVATIVES AS SGC STIMULATORS<br/>[FR] DÉRIVÉS DE PYRAZOLE UTILISÉS COMME STIMULATEURS DE SGC
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2016044447A1

  公开（公告）日：2016-03-24

  There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

  描述了咪唑和吡唑衍生物，它们可作为sGC的刺激剂，特别是NO独立、依赖血红素的刺激剂。这些化合物还可用于治疗、预防或管理本文中披露的各种疾病。
• THERAPEUTIC ISOXAZOLE COMPOUNDS
  申请人：Kaplan Alan P.

  公开号：US20090062252A1

  公开（公告）日：2009-03-05

  The invention provides a compound of formula I: wherein A 1 , A 2 , A 3 , R 1 , X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.

  本发明提供了一种式子为I的化合物：其中A1、A2、A3、R1、X、Y和B具有本文所述的任何值，以及这些化合物的盐、包含这些化合物的组合物和包括给予这些化合物的治疗方法。这些化合物是单胺氧化酶B（MAO-B）酶功能的抑制剂，对于改善动物的认知功能和治疗精神障碍是有用的。
• Therapeutic isoxazole compounds
  申请人：Dart NeuroScience (Cayman) Ltd

  公开号：US08222243B2

  公开（公告）日：2012-07-17

  The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.

  本发明提供了一种化合物I的公式： 其中，A1、A2、A3、R1、X、Y和B具有以下任意值，以及这些化合物的盐、包含这些化合物的组合物和包括这些化合物的治疗方法。这些化合物是单胺氧化酶B（MAO-B）酶功能的抑制剂，对于改善动物的认知功能和治疗精神障碍非常有用。
• Azaquinazoline Inhibitors of Atypical Protein Kinase C
  申请人：Cancer Research Technology Limited

  公开号：US20140113882A1

  公开（公告）日：2014-04-24

  The present application provides a compound of formula (I) or a salt thereof, wherein R 7 , R 8 , R 9 , G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

  本申请提供了式（I）的化合物或其盐，其中R7，R8，R9，G和X的定义如本文所述。本申请还描述了包含该化合物的组合物。式（I）的化合物及其盐具有aPKC抑制活性，并可用于治疗增生性疾病。
• Preparation of iminosugars from aminopolyols <i>via</i> selective oxidation using galactose oxidase
  作者：Kathryn Yeow、Marianne B. Haarr、Jimmy Muldoon、Elaine O'Reilly

  DOI：10.1039/d2cc04989a

  日期：——

  Selective oxidation of minimally protected aminopolyols, using galactose oxidase variant F₂, affords biologically relevant iminosugars.

  使用半乳糖氧化酶F2变种，选择性氧化最小保护氨基多醇，可以得到具有生物学意义的亚胺糖。