(4-甲氧基-苯基)-(6-甲基-喹唑啉-4-基)-胺盐酸盐 | 338736-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: (4-甲氧基-苯基)-(6-甲基-喹唑啉-4-基)-胺盐酸盐
• 英文名称: LY 456236 Hydrochloride
• 英文别名: 6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine;hydrochloride
• CAS: 338736-46-2；338738-57-1
• 化学式: C16H16ClN3O2
• 分子量: 317.77
• InChiKey: AVKFOWUSTVWZQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1230225A2

  公开（公告）日：2002-08-14
• METHODS OF INCREASING LIGHT RESPONSIVENESS IN A SUBJECT WITH RETINAL DEGENERATION
  申请人：Jensen Ralph J.

  公开号：US20150038464A1

  公开（公告）日：2015-02-05

  Disclosed herein are methods of increasing retinal responsiveness to light in a subject, such as a subject with retinal degeneration. The disclosed methods include administering one or more compounds that decrease or inhibit γ-aminobutyric acid (GABA) signaling to a subject with retinal degeneration. In some embodiments, the methods include selecting a subject with retinal degeneration and administering a γ-aminobutyric acid C (GABA C ) receptor antagonist to the subject. In one example, the GABA C receptor antagonist is (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA). In other embodiments, the methods include selecting a subject with retinal degeneration and administering a metabotropic glutamate receptor (mGluR) antagonist to the subject. In one example, the mGluR antagonist is a mGlu1 receptor antagonist (for example, JNJ16259685).
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2001032632A2

  公开（公告）日：2001-05-10

  The present invention relates to the use of certain 4-substituted pyrimidine derivatives as mGluR1 antagonists, to novel 4-substituted pyrimidine derivatives, to pharmaceutical formulations comprising 4-substituted pyrimidine derivatives, to a process for preparing 4-substituted pyrimidine derivatives and to intermediates useful in the preparation of 4-substituted pyrimidine derivatives.