(4E)-4-(氨基-甲氧基亚甲基)-2-硝基环己a-2,5-二烯-1-酮 | 78200-33-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: (4E)-4-(氨基-甲氧基亚甲基)-2-硝基环己a-2,5-二烯-1-酮
• 英文名称: Methyl 4-hydroxy-3-nitrobenzimidat
• 英文别名: Methyl-4-hydroxy-3-nitrobenzimidate；methyl 4-hydroxy-3-nitrobenzenecarboximidate
• CAS: 78200-33-6
• 化学式: C₈H₈N₂O₄
• 分子量: 196.163
• InChiKey: BSFKABRSENRNFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  99.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Immunogenic complex, a method for producing the same, and the use thereof as an immune stimulant, vaccines and reagents
  申请人：Morein, Bror

  公开号：EP0180564A2

  公开（公告）日：1986-05-07

  The invention relates to a process for preparing an immunogenic complex comprising a carrier molecule prepared by mixing viruses, mycoplasmas, bacterias, animal cells or proteins or peptides having hydrophobic regions with one or more solubilizing agents, whereby a complex having been formed between proteins or peptides and solubilizing agents, whereafter the proteins or the peptides have been separated from the solubilizing agent in the presence of a glycoside solution which contains one or more glycosides having hydrophobic and hydrophilic regions in a concentration of at least the critical micellular concentration, or alternatively have been separated from the solubilizing agent and transferred directly to the aforementioned glycoside solution, and the carrier molecule being bound to one or more molecules selected from peptides, proteins, carbohydrates, lipoproteins, glycolipides or small molecules, such as biotine, by coupling with known methods between functional coupling groups in the bound molecules and functional groups in the peptides or the proteins in the carrier molecule. The invention also relates to a method for preparing such immunogenic complexes, compositions, vaccines containing such complexes and to reagents.

  本发明涉及一种制备免疫原性复合物的工艺，该复合物包括通过将病毒、支原体、细菌、动物细胞或具有疏水区域的蛋白质或肽与一种或多种增溶剂混合制备的载体分子，从而在蛋白质或肽和增溶剂之间形成复合物、之后，蛋白质或肽在糖苷溶液中与增溶剂分离，糖苷溶液中含有一种或多种具有疏水和亲水区域的糖苷，浓度至少为临界微孔浓度、载体分子与一种或多种分子结合，这些分子选自肽、蛋白质、碳水化合物、脂蛋白、糖脂或小分子（如生物碱），结合分子中的官能偶联基团与载体分子中的肽或蛋白质中的官能基团之间通过已知方法偶联。 本发明还涉及制备此类免疫原复合物、组合物、含有此类复合物的疫苗的方法以及试剂。