(5E)-5-[(3-羟基-4-甲氧基-苯基)亚甲基]-2-硫代-四氢噻唑-4-酮 | 69505-47-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: (5E)-5-[(3-羟基-4-甲氧基-苯基)亚甲基]-2-硫代-四氢噻唑-4-酮
• 中文别名: (5E)-5-(3-羟基-4-甲氧基苄亚基)-2-硫代-1,3-噻唑烷-4-酮；(5E)-5-(3-羟基-4-甲氧基-苯亚甲基)-2-硫代-四氢噻唑-4-酮；(5E)-5-[(3-羟基-4-甲氧苯基)亚甲基]-2-硫基亚甲基-1,3-四氢噻唑-4-酮；(5E)-5-[(3-羟基-4-甲氧基-苯基)亚甲基]-2-硫基亚甲基-1,3-四氢噻唑-4-酮；[2-(5-氯-1H-吲哚-3-基)-1-甲基乙基]胺盐酸盐；(5E)-5-[(3-羟基-4-甲氧苯基)亚甲基]-2-硫代-4-四氢噻唑酮；5-(3-羟基-4-甲氧基-苯亚甲基)-2-硫代-四氢噻唑-4-酮
• 英文名称: 5-(3-hydroxy-4-methoxy-benzylidene)-2-thioxo-thiazolidin-4-one
• 英文别名: 5-[(3-hydroxy-4-methoxyphenyl)methylene]-2-thioxo-4-thiazolidinone；(5E)-5-(3-hydroxy-4-methoxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one；(5E)-5-[(3-hydroxy-4-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS: 69505-47-1
• 化学式: C₁₁H₉NO₃S₂
• 分子量: 267.329
• InChiKey: PCTZLDOIVAVMME-WEVVVXLNSA-N

物化性质

• 熔点：
  220-221 °C(Solv: acetone (67-64-1))
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2934999090

文献信息

• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR
  申请人：Chung Hae Young

  公开号：US20140023603A1

  公开（公告）日：2014-01-23

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白皮肤、抗氧化和PPAR活性的新化合物及其医疗用途，该化合物具有美白皮肤的活性，可抑制酪氨酸酶，因此适用于用于美白皮肤的药物组合物或化妆品；具有抗氧化活性，因此适用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此适用于用于预防和治疗肥胖、代谢性疾病或心血管疾病的药物组合物或保健食品。
• INHIBITORS OF BACTERIAL BIOFILM FORMATION
  申请人：Opperman Timothy J.

  公开号：US20110098323A1

  公开（公告）日：2011-04-28

  Organic compounds are described for use in inhibiting or preventing formation of bacterial biofilms.

  有机化合物被描述为用于抑制或预防细菌生物膜的形成。
• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF
  申请人：Pusan National University Industry-University Cooperation Foundation

  公开号：US20160102065A1

  公开（公告）日：2016-04-14

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白、抗氧化和PPAR活性的新化合物及其医疗用途。该化合物具有抑制酪氨酸酶的美白活性，因此可用于美白药物组合物或化妆品产品；具有抗氧化活性，因此可用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖症、代谢疾病或心血管疾病的药物组合物或保健食品。
• Arylmethylenyl derivatives of thiazolidnones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflamatory agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0343643A2

  公开（公告）日：1989-11-29

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula having activity useful for treating allergies and inflammation.

  本发明涉及所选的新型化合物，以及已知和所选的新型化合物的药物组合物和使用方法，这两种化合物的化学式均为 具有治疗过敏症和炎症的活性。
• Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease
  申请人：ELI LILLY AND COMPANY

  公开号：EP0587377A2

  公开（公告）日：1994-03-16

  Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds, process for preparing same and pharmaceutical formulations thereof, are also provided.

  本发明提供了利用某些罗丹宁衍生物治疗高血糖和阿尔茨海默病的方法。在本方法中使用的某些罗丹宁衍生物是新颖的，因此还提供了此类化合物、其制备工艺和药物制剂。