(6R,8S)-3-氯-6-二甲基氨基-8-苯基-5,6,7,8-四氢萘-2-醇 | 152722-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: (6R,8S)-3-氯-6-二甲基氨基-8-苯基-5,6,7,8-四氢萘-2-醇
• 英文名称: (2R,4S)-trans-(+)-6-hydroxy-7-chloro-4-phenyl-2-dimethylaminotetralin
• 英文别名: (2R,4S)-4-phenyl-6-hydroxy-7-chloro-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine；1-Phenyl-3-dimethylamino-6-chloro-7-hydroxy-1,2,3,4-tetrahydronaphthalene；(6R,8S)-3-chloro-6-(dimethylamino)-8-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol
• CAS: 152722-42-4
• 化学式: C₁₈H₂₀ClNO
• 分子量: 301.816
• InChiKey: XZCKHECUBFUSAR-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (6R,8S)-3-氯-6-二甲基氨基-8-苯基-5,6,7,8-四氢萘-2-醇 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 (2R,4S)-4-phenyl-6-hydroxy-7-chloro-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
  参考文献：
  名称：

  [EN] SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS
  [FR] COMPOSÉS DE CIBLAGE DE RÉCEPTEUR DE SÉROTONINERGIQUE ET PROCÉDÉS ASSOCIÉS

  摘要：

  这项发明涉及部分用于治疗各种疾病的组合物和方法，其中这些疾病与在血清素受体上的结合有关。这些组合物包括手性四氢萘-2-胺衍生物。因此，本发明提供了用于激动或拮抗一个或多个血清素受体的组合物和方法，这些组合物和方法可用于治疗各种神经精神疾病或障碍，包括但不限于孤独症谱系障碍（ASD）或相关症状。

  公开号：

  WO2015179366A1

文献信息

• Serotonin receptor-targeting compounds and methods
  申请人：Northeastern University

  公开号：US11021435B2

  公开（公告）日：2021-06-01

  This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.

  本发明部分涉及可用于治疗各种疾病（包括与血清素受体结合有关的疾病）的组合物和方法。这些组合物包括手性四氢萘-2-胺衍生物。因此，本发明提供了激动或拮抗一种或多种血清素受体的组合物和方法，这些组合物和方法可用于治疗各种神经精神疾病或紊乱，包括但不限于自闭症谱系障碍（ASD）或相关症状。
• SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS
  申请人：Northeastern University

  公开号：EP3145906A1

  公开（公告）日：2017-03-29
• Serotonin Receptor-Targeting Compounds and Methods
  申请人：Northeastern University

  公开号：US20170081273A1

  公开（公告）日：2017-03-23

  This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.
• [EN] SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS DE CIBLAGE DE RÉCEPTEUR DE SÉROTONINERGIQUE ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV NORTHEASTERN

  公开号：WO2015179366A1

  公开（公告）日：2015-11-26

  This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.

  这项发明涉及部分用于治疗各种疾病的组合物和方法，其中这些疾病与在血清素受体上的结合有关。这些组合物包括手性四氢萘-2-胺衍生物。因此，本发明提供了用于激动或拮抗一个或多个血清素受体的组合物和方法，这些组合物和方法可用于治疗各种神经精神疾病或障碍，包括但不限于孤独症谱系障碍（ASD）或相关症状。