5-[(E)-[(3-chlorophenyl)hydrazinylidene]methyl]-2-methoxyphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-[(E)-[(3-chlorophenyl)hydrazinylidene]methyl]-2-methoxyphenol
• 化学式: C₁₄H₁₃ClN₂O₂
• 分子量: 276.72
• InChiKey: QUWLDXOXVUXDFC-CXUHLZMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  53.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TGF-beta enhancing compositions for cartilage repair and methods related thereto
  申请人：EMORY UNIVERSITY

  公开号：US10322125B2

  公开（公告）日：2019-06-18

  This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and regeneration comprising administering an effective amount of a composition comprising a compound disclosed herein to the subject or implanting a cartilage matrix comprising a compound disclosed herein in the subject. In certain embodiments, the compound is used locally such as injection at any desired site of cartilage formation.

  本公开涉及用于软骨修复的化合物和组合物及其相关方法。在某些实施方案中，本公开涉及诱导软骨生长和再生的方法，包括向受试者施用有效量的包含本文公开的化合物的组合物，或在受试者体内植入包含本文公开的化合物的软骨基质。在某些实施方案中，该化合物用于局部，如注射到软骨形成的任何所需部位。
• TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO
  申请人：EMORY UNIVERSITY

  公开号：US20150374694A1

  公开（公告）日：2015-12-31

  This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and regeneration comprising administering an effective amount of a composition comprising a compound disclosed herein to the subject or implanting a cartilage matrix comprising a compound disclosed herein in the subject. In certain embodiments, the compound is used locally such as injection at any desired site of cartilage formation.
• [EN] TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO<br/>[FR] COMPOSITIONS FAVORISANT TGF-BÊTA POUR LA RÉPARATION DU CARTILAGE ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV EMORY

  公开号：WO2014130411A1

  公开（公告）日：2014-08-28

  This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and regeneration comprising administering an effective amount of a composition comprising a compound disclosed herein to the subject or implanting a cartilage matrix comprising a compound disclosed herein in the subject. In certain embodiments, the compound is used locally such as injection at any desired site of cartilage formation.