2-fluoro-N-[2-(4-hydroxyphenyl)ethyl]acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-fluoro-N-[2-(4-hydroxyphenyl)ethyl]acetamide
• 化学式: C₁₀H₁₂FNO₂
• 分子量: 197.21
• InChiKey: CYTMYFLJDROEDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Methods and compositions for bisubstrate inhibitors of acetyltransferases
  申请人：The Government of the United States of America, Department of Health & Human Services

  公开号：US20020002144A1

  公开（公告）日：2002-01-03

  The present invention provides a method of producing a bisubstrate inhibitor in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell. Further provided is a method of inhibiting the activity of an acetyltransferase in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell under conditions whereby a bisubstrate inhibitor will be produced, thereby inhibiting the activity of the acetyltransferase in the cell.

  本发明提供了一种在细胞中生产双基底抑制剂的方法，包括将细胞中存在的乙酰基转移酶的乙酰基受体底物的烷基化衍生物引入细胞。本发明还提供了一种抑制细胞中乙酰转移酶活性的方法，包括在将产生双基底抑制剂的条件下将细胞中存在的乙酰转移酶的乙酰受体底物的烷基化衍生物导入细胞，从而抑制细胞中乙酰转移酶的活性。
• METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES
  申请人：The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：EP1212056A1

  公开（公告）日：2002-06-12
• [EN] METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES<br/>[FR] TECHNIQUES ET COMPOSITIONS POUR INHIBITEURS D'ACETYLTRANSFERASES A DEUX SUBSTRATS
  申请人：US GOV HEALTH & HUMAN SERV

  公开号：WO2001012185A1

  公开（公告）日：2001-02-22

  The present invention provides a method of producing a bisubstrate inhibitor in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell. Further provided is a method of inhibiting the activity of an acetyltransferase in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell under conditions whereby a bisubstrate inhibitor will be produced, thereby inhibiting the activity of the acetyltransferase in the cell.