1'-(Cyclopropylmethyl)-7-methoxyspiro[3,4-dihydronaphthalene-2,4'-piperidine]-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1'-(Cyclopropylmethyl)-7-methoxyspiro[3,4-dihydronaphthalene-2,4'-piperidine]-1-one
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.4
• InChiKey: KLQRUHUFPJMPKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Tricyclic analgesics
  申请人：——

  公开号：US20040266802A1

  公开（公告）日：2004-12-30

  A tricyclic compound of Formula (I): wherein: R 1 is hydrogen or hydroxy; R 2 is hydrogen or hydroxy; or R 1 and R 2 together are oxygen; A is a bond, CH 2 , CH CH 3 , CH 2 CH 2 or C(CH 3 ) 2 ; R 3 and R 4 are the same or different and are hydrogen, halo, C 1 -C 6 alkyl, C 1 -C 4 alkoxy, trifluoromethyl NO 2 , COR 6 , COOR 6 or NR 6 R 7 , wherein R 6 and R 7 are the same or different and are hydrogen, C 1 -C 6 alkyl or benzyl; R 5 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, (O═C)—C 1-6 alkyl, (O═C)—C 2-6 alkenyl, (O═C)—C 3-6 cycloalkyl wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C 3 -C 6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders. 1

  公式（I）的三环化合物：其中：R 1 为氢或羟基；R 2 为氢或羟基；或R 1 和R 2 一起为氧；A为键，CH 2 ，CH CH 3 ，CH 2 CH 2 或C(CH 3 ) 2 ；R 3 和R 4 相同或不同，为氢，卤素，C 1 -C 6 烷基，C 1 -C 4 烷氧基，三氟甲基NO 2 ，COR 6 ，COOR 6 或NR 6 R 7 ，其中R 6 和R 7 相同或不同，为氢，C 1 -C 6 烷基或苄基；R 5 为氢，C 1-6 烷基，C 2-6 烯基，C 3-6 环烷基，（O═C）—C 1-6 烷基，（O═C）—C 2-6 烯基，（O═C）—C 3-6 环烷基，其中所述烷基，烯基和环烷基基团可被1、2或3个来自卤素，C 3 -C 6 环烷基，苯基或取代苯基的基团取代，以及其盐，特别适用于治疗神经病性疼痛和其他中枢神经系统疾病等适应症。
• TRICYCLIC ANALGESICS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1235808A2

  公开（公告）日：2002-09-04
• [EN] TRICYCLIC ANALGESICS<br/>[FR] ANALGESIQUES TRICYCLIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2000075116A2

  公开（公告）日：2000-12-14

  A tricyclic compound of Formula (I): wherein: R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; or R?1 and R2¿ together are oxygen; A is a bond, CH¿2?, CH CH3, CH2 CH2 or C(CH3)2; R?3 and R4¿ are the same or different and are hydrogen, halo, C¿1?-C6 alkyl, C1-C4 alkoxy, trifluoromethyl, NO2, COR?6, COOR6 or NR6R7¿, wherein R?6 and R7¿ are the same or different and are hydrogen, C¿1?-C6 alkyl or benzyl; R?5¿ is hydrogen, C¿1-6? alkyl, C2-6 alkenyl, C3-6 cycloalkyl, (O=C)-C1-6 alkyl, (O=C)-C2-6 alkenyl, (O=C)-C3-6 cycloalkyl, wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C3-C6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.