1-[4-(1H-imidazol-5-yl)piperidin-1-yl]-4-(N-phenylanilino)butan-1-one

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[4-(1H-imidazol-5-yl)piperidin-1-yl]-4-(N-phenylanilino)butan-1-one
• 化学式: C₂₄H₂₈N₄O
• 分子量: 388.5
• InChiKey: PIYZQJWSJYUUKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PIPERIDYL-IMIDAZOLE DERIVATIVES, THEIR PREPARATIONS AND THERAPEUTIC USES<br/>[FR] DERIVES DE PIPERIDYLE-IMIDAZOLE, PREPARATIONS DANS LESQUELLES ILS ENTRENT ET UTILISATIONS THERAPEUTIQUES DE CES DERNIERES
  申请人：NOVO NORDISK AS

  公开号：WO2000064884A1

  公开（公告）日：2000-11-02

  Piperidyl-imidazole derivatives pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders, in which an interaction with the histamine H3 receptor is beneficial.