2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone
• 英文别名: 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone；(R,S)-2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone；2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-hydroxy-5-methyl-2-oxohexyl)-3H-isoindol-1-one
• 化学式: C₂₃H₂₂ClN₃O₃
• 分子量: 423.899
• InChiKey: ADHYPRBHQVZOTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxo-5-hexen-1-yl)-1-isoindolinone 在 sodium hydroxide 、 硫酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone
  参考文献：
  名称：

  US5494915

  摘要：

  公开号：

文献信息

• Methods, kits and compositions for using pyrrole derivatives against anxiety
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1254660A2

  公开（公告）日：2002-11-06

  The present invention provides methods and kits for treating obsessive-compulsive disorder, acute stress disorder, post traumatic stress disorder, social anxiety disorder, somatization disorder, specific social phobia, premenstrual dysphoric disorder, anxiety associated with a medical condition, adjustment disorder with anxious mood, dysthymia, specific phobia or fibromyalgia using a compound of Formula I or a pharmaceutically acceptable salt, optical isomer or prodrug thereof The present invention also provides compositions comprising a compound of Formula I or a pharmaceutically acceptable salt, optical isomer or prodrug thereof and an additional compound useful to treat the aforementioned conditions.

  本发明提供了使用式 I 化合物或其药学上可接受的盐、光学异构体或原药治疗强迫症、急性应激障碍、创伤后应激障碍、社交焦虑障碍、躯体化障碍、特定社交恐惧症、经前期情感障碍、与疾病相关的焦虑、焦虑情绪的适应障碍、癔症、特定恐惧症或纤维肌痛的方法和试剂盒。 本发明还提供了由式 I 化合物或其药学上可接受的盐、光学异构体或原药和另一种用于治疗上述病症的化合物组成的组合物。
• Methods, kits and compositions for using pyrrole derivatives to combat anxiety
  申请人：Indevus Pharmaceuticals, Inc.

  公开号：EP1642576A2

  公开（公告）日：2006-04-05

  The present invention provides methods and kits for treating social anxiety disorder, using a compound which is 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone or 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone or a pharmaceutically acceptable salt, optical isomer or prodrug thereof. The present invention also provides compositions comprising said compound or a pharmaceutically acceptable salt, optical isomer or prodrug thereof and an additional compound useful to treat the aforementioned conditions.

  本发明提供了治疗社交焦虑症的方法和试剂盒，使用的化合物是2-(7-氯-1,8-萘啶-2-基)-3-(5-甲基-2-氧代己基)-1-异吲哚啉酮或2-(7-氯-1,8-萘啶-2-基)-3-(5-甲基-5-羟基-2-氧代己基)-1-异吲哚啉酮或其药学上可接受的盐、光学异构体或原药。 本发明还提供了包含上述化合物或其药学上可接受的盐、光学异构体或原药的组合物，以及另一种用于治疗上述病症的化合物。
• Methods, kits and compositions for using pyrrole derivatives
  申请人：——

  公开号：US20030022915A1

  公开（公告）日：2003-01-30

  The present invention provides methods and kits for treating obsessive-compulsive disorder, acute stress disorder, post traumatic stress disorder, social anxiety disorder, somatization disorder, specific social phobia, premenstrual dysphoric disorder, anxiety associated with a medical condition, adjustment disorder with anxious mood, dysthymia, specific phobia or fibromyalgia using a compound of Formula I or a pharmaceutically acceptable salt, optical isomer or prodrug thereof 1 The present invention also provides compositions comprising a compound of Formula I or a pharmaceutically acceptable salt, optical isomer or prodrug thereof and an additional compound useful to treat the aforementioned conditions.

  本发明提供了使用式 I 化合物或其药学上可接受的盐、光学异构体或原药治疗强迫症、急性应激障碍、创伤后应激障碍、社交焦虑障碍、躯体化障碍、特定社交恐惧症、经前期情感障碍、与疾病相关的焦虑、焦虑情绪的适应障碍、癔症、特定恐惧症或纤维肌痛的方法和试剂盒。 1 本发明还提供了由式 I 化合物或其药学上可接受的盐、光学异构体或原药和另一种用于治疗上述病症的化合物组成的组合物。
• Methods for using pyrrole derivatives against obsessive compulsive disorder
  申请人：Indevus Pharmaceuticals, Inc.

  公开号：EP1254660B1

  公开（公告）日：2006-06-28
• Use of pyrrole derivatives to combat anxiety
  申请人：Indevus Pharmaceuticals, Inc.

  公开号：EP1642576B1

  公开（公告）日：2009-03-11