4-(4-hydroxybenzyl)-4,5-dihydro-1,3-thiazol-2-ylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(4-hydroxybenzyl)-4,5-dihydro-1,3-thiazol-2-ylamine
• 英文别名: 4-[(2-Amino-4,5-dihydro-1,3-thiazol-4-yl)methyl]phenol
• 化学式: C₁₀H₁₂N₂OS
• 分子量: 208.284
• InChiKey: DKWPXBLXLUCVBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase
  申请人：——

  公开号：US20020022631A1

  公开（公告）日：2002-02-21

  The present invention relates to the use of 2-aminothiazoline derivatives of formula: 1 in which either R 1 is a hydrogen atom or an alkyl radical and R 2 is an alkyl, -alk-NH 2 , —CH 2 —R 3 , —CH 2 —S—R 4 or phenyl radical substituted with a nitro or —NH—C(═NH)CH 3 radical, or R 1 is an alkyl radical and R 2 is a hydrogen atom, R 3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R 4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, as inhibitors of inducible NO-synthase.

  本发明涉及通式1的2-氨基噻唑啉衍生物的用途： 其中，R1为氢原子或烷基基团，R2为烷基、-烷-NH2、—CH2—R3、—CH2—S—R4或被硝基或—NH—C(═NH)CH3基团取代的苯基基团；或者，R1为烷基基团，R2为氢原子，R3为(3-6C)环烷基、吡啶基、吡啶基N-氧化物、噻吩基、噻唑基、咪唑基、吡嗪基、三唑基或苯基基团，或被硝基、羟基或羧基基团取代的苯基基团，R4代表吡啶基或吡啶基N-氧化物基团，烷代表亚烷基基团，或其药学上可接受的盐，作为诱导型NO合酶抑制剂。
• Use of 2-aminothiazoline derivatives as inhibitors of inducible NO-synthase
  申请人：——

  公开号：US20020187987A1

  公开（公告）日：2002-12-12

  The present invention relates to the use of 2-aminothiazoline derivatives of formula I: 1 in which either R 1 is a hydrogen atom or an alkyl radical and R 2 is an alkyl, -alk-NH 2 , —CH 2 —R 3 , —CH 2 —S—R 4 or phenyl radical substituted with a nitro or —NH—C(═NH)CH 3 radical, or R 1 is an alkyl radical and R 2 is a hydrogen atom, R 3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R 4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, as inhibitors of inducible NO-synthase.

  本发明涉及使用公式I中的2-氨基噻唑衍生物：1其中R1为氢原子或烷基基团，R2为烷基，-烷基-NH2，—CH2—R3，—CH2—S—R4或被硝基或—NH—C（═NH）CH3基团取代的苯基基团，或R1为烷基基团，R2为氢原子，R3为（3-6C）环烷基、吡啶基、吡啶N-氧化物、噻吩基、噻唑基、咪唑基、吡嗪基、三唑基或苯基基团或被硝基、羟基或羧基取代的苯基基团，R4表示吡啶基或吡啶N-氧化物基团，烷基表示烷基基团，或其药学上可接受的盐，作为诱导型NO合酶的抑制剂。
• 2-aminothiazoline derivatives and process for preparing the same
  申请人：——

  公开号：US20020198243A1

  公开（公告）日：2002-12-26

  The present invention relates to a class of 2-aminothiazoline derivatives of formula I: 1 in which either R 1 is a hydrogen atom or an alkyl radical and R 2 is an alkyl, -alk-NH 2 , —CH 2 —R 3 , —CH 2 —S—R 4 or phenyl radical substituted with a nitro or —NH—C(═NH)CH 3 radical, or R 1 is an alkyl radical and R 2 is a hydrogen atom, R 3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R 4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, which are useful as inhibitors of inducible NO-synthase.

  本发明涉及一类2-氨基噻唑啉衍生物，其化学式为I:1，其中R1为氢原子或烷基基团，R2为烷基、-烷基-NH2、—CH2—R3、—CH2—S—R4或取代有硝基或—NH—C(═NH)CH3基团的苯基基团，或R1为烷基基团，R2为氢原子，R3为(3-6C)环烷基、吡啶基、吡啶N-氧化物、噻吩基、噻唑基、咪唑基、吡嗪基、三唑基或苯基基团或取代有硝基、羟基或羧基的苯基基团，R4表示吡啶基或吡啶N-氧化物基团，alk表示烷基链，或其药学上可接受的盐，其作为诱导型NO合酶的抑制剂具有用途。
• DERIVES DE 2-AMINOTHIAZOLINE ET LEUR UTILISATION COMME INHIBITEURS DE NO-SYNTHASE
  申请人：Aventis Pharma S.A.

  公开号：EP1299365B1

  公开（公告）日：2005-09-28
• US6451821B1
  申请人：——

  公开号：US6451821B1

  公开（公告）日：2002-09-17