tilidine mesylate | 278195-33-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tilidine mesylate
• 英文别名: ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate;methanesulfonic acid
• CAS: 278195-33-8
• 化学式: CH₄O₃S*C₁₇H₂₃NO₂
• 分子量: 369.482
• InChiKey: YQAMSTVQJSFYIB-KALLACGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Crystalline forms of Tilidine Mesylate
  申请人：Hexal AG

  公开号：EP2168945A1

  公开（公告）日：2010-03-31

  The present invention provides novel crystalline forms of Tilidine Mesylate designated as forms I and II and processes for their preparation. The form I is a hygroscopic and crystalline Tilidine Mesylate, whereas the form II is not hygroscopic, water containing and crystalline.

  本发明提供了甲磺酸替利定的新型结晶形式 I 和 II 及其制备工艺。I 型甲磺酸替利定具有吸湿性和结晶性，而 II 型甲磺酸替利定不具有吸湿性、含水和结晶性。
• Granulate comprising an oily substance, corresponding production method and tablet
  申请人：Klokkers Karin

  公开号：US20060147529A1

  公开（公告）日：2006-07-06

  The invention relates to a process for the preparation of granules comprising an oily substance. It relates also to granules for a pharmaceutical formulation and to a tablet as a product of further processing.

  本发明涉及一种含油物质颗粒的制备工艺。本发明还涉及用于药物制剂的颗粒和作为进一步加工产品的片剂。
• TILIDINE MESYLATE, PROCESSES FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：RUSSINSKY LIMITED

  公开号：EP1073625A1

  公开（公告）日：2001-02-07
• KONTROLLIERT FREISETZENDE PHARMAZEUTISCHE ZUSAMMENSETZUNG MIT TILIDINMESYLAT ALS WIRKSTOFF
  申请人：HEXAL AG

  公开号：EP1140031A1

  公开（公告）日：2001-10-10
• Absorbing agents and cover layer which is impermeable to active substances and which contains channel-formers or removable protective layer of a transdermal therapeutic system
  申请人：——

  公开号：US20040047901A1

  公开（公告）日：2004-03-11

  This present invention concerns a cover layer that is impermeable to the active substances and/or a removable protective layer of a transdermal therapeutic system, comprising a thermoplastic film which either directly contains the absorbing agents and channel-forming agents or is coated with a polymer support (thermoplast) containing these substances. The polymer support can either be applied over the entire surface of the film or in patterns, directly during production. The thermoplastic film that is used and the polymer support can be made from either the same or different materials.