(1R)-2-(2-dibenzothiophen-3-yloxyethylamino)-1-(4-methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: (1R)-2-(2-dibenzothiophen-3-yloxyethylamino)-1-(4-methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)ethanol
• 化学式: C₂₅H₂₆N₂O₅S₂
• 分子量: 498.6
• InChiKey: DTNWXBHANLALQG-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NOVEL HETEROCYCLIC COMPOUNDS AND DRUG COMPOSITIONS CONTAINING THE SAME
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1142883A1

  公开（公告）日：2001-10-10

  The present invention is directed to a compound of the general formula (I): wherein R1 represents a hydrogen atom, a methyl group or SO2R3; R2 represents O, S or H2; R2' represents O or H2; R3 represents a lower alkyl group or NH4R4'; R4 and R4' may be the same or different and represent a hydrogen atom, a lower alkyl group or a benzyl group; R5 represents a hydrogen atom or a lower alkyl group; k and m are zero or 1; A represents the general formula (II) or (III): X1 represents a secondary nitrogen atom, an oxygen atom, a sulfur atom or a methylene group; n is 1 or 2; X2 represents a secondary nitrogen atom, an oxygen atom or a sulfur atom; and, R6, R7 and R8 are a hydrogen atom or the like; and a salt thereof. The compound of the present invention provides a pharmaceutical composition for treating and preventing β3-associated diseases, such as diabetes, obesity and hyperlipidemia. The composition is particularly suitable for oral administration.

  本发明涉及通式（I）的化合物： 其中 R1 代表氢原子、甲基或 SO2R3；R2 代表 O、S 或 H2；R2'代表 O 或 H2；R3 代表低级烷基或 NH4R4'；R4 和 R4'可以相同或不同，并代表氢原子、低级烷基或苄基；R5 代表氢原子或低级烷基；k 和 m 为 0 或 1；A 代表通式（II）或（III）： X1代表仲氮原子、氧原子、硫原子或亚甲基；n为1或2；X2代表仲氮原子、氧原子或硫原子；以及，R6、R7和R8为氢原子或类似物；及其盐。本发明的化合物提供了一种药物组合物，用于治疗和预防与β3相关的疾病，如糖尿病、肥胖症和高脂血症。该组合物特别适合口服给药。