6-(Dipropylamino)-7-methyl-5,6,7,8-tetrahydronaphthalene-1,4-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-(Dipropylamino)-7-methyl-5,6,7,8-tetrahydronaphthalene-1,4-diol
• 化学式: C₁₇H₂₇NO₂
• 分子量: 277.4
• InChiKey: HTIBOHODNYPNCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Inhibitors of the nitration of amyloid ß peptides and their uses in the diagnosis and treatment of alzheimer's disease
  申请人：Rheinische Friedrich-Wilhelms-Universität Bonn

  公开号：EP2273273A1

  公开（公告）日：2011-01-12

  The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-β peptide (Aβ), comprising the steps of a) contacting at least one Aβ-peptide and/or the nitrated forms thereof with at least one candidate inhibitor that potentially specifically binds to a region in said Aβ-peptide capable of being nitrated, and b) detecting said inhibitor specifically binding to said region in said Aβ-peptide through detecting a lack of or a reduced aggregation of said at least one Aβ-peptide. The present invention is further directed at improved methods for treating neuronal degradation and particularly Alzheimer's disease, based on said inhibitor. The present invention is further directed at methods for diagnosing the aggregation of Aβ-peptide in the context of neuronal degradation and particularly Alzheimer's disease.

  本发明涉及一种鉴定淀粉样β肽（Aβ）聚集抑制剂的方法，包括以下步骤 a) 将至少一种Aβ肽和/或其硝化形式与至少一种候选抑制剂接触，所述候选抑制剂可能与所述Aβ肽中能够被硝化的区域特异性结合、b) 通过检测所述至少一种 Aβ 肽的聚集缺乏或聚集减少情况，检测所述抑制剂与所述 Aβ 肽中所述区域的特异性结合情况。本发明进一步涉及基于所述抑制剂治疗神经元退化，特别是阿尔茨海默病的改进方法。本发明进一步涉及在神经元退化，特别是阿尔茨海默病的情况下诊断Aβ肽聚集的方法。
• INHIBITORS OF THE NITRATION OF AMYLOID ß PEPTIDES AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Rheinische Friedrich-Wilhelms-Universität Bonn

  公开号：EP2454599A1

  公开（公告）日：2012-05-23
• [EN] INHIBITORS OF THE NITRATION OF AMYLOID ß PEPTIDES AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE LA NITRURATION DE PEPTIDES D'AMYLOÏDE SS ET LEURS UTILISATIONS DANS LE DIAGNOSTIC ET LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：UNIV BONN

  公开号：WO2011006871A1

  公开（公告）日：2011-01-20

  The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-β peptide (Aβ), comprising the steps of a) contacting at least one Aβ-peptide and/or the nitrated forms thereof with at least one candidate inhibitor that potentially specifically binds to a region in said Aβ-peptide capable of being nitrated, and b) detecting said inhibitor specifically binding to said region in said Aβ-peptide through detecting a lack of or a reduced aggregation of said at least one Aβ-peptide. The present invention is further directed at improved methods for treating neuronal degradation and particularly Alzheimer's disease, based on said inhibitor. The present invention is further directed at methods for diagnosing the aggregation of Aβ-peptide in the context of neuronal degradation and particularly Alzheimer's disease.