4-(5-Ethylphenazin-5-ium-1-yl)oxybutanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(5-Ethylphenazin-5-ium-1-yl)oxybutanoic acid
• 化学式: C18H19N2O3+
• 分子量: 311.4
• InChiKey: JKBSCAPRNLCSSB-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PHENAZINIUM MEDIATORS<br/>[FR] MÉDIATEURS PHÉNAZINIUM
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2015158645A1

  公开（公告）日：2015-10-22

  The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.

  本发明涉及一种化学化合物或其盐或溶剂的1-氨基苯并嗪衍生物及其用途。本发明还涉及一种化学基质和一种包括上述化学化合物的测试元素。此外，本发明还涉及一种测定样品中分析物含量的方法，包括将该样品与本发明中的化学基质接触，估计液体样品存在的情况下化学基质释放或消耗的电子数量，从而确定液体样品中分析物的数量。
• BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY
  申请人：Wilsey Christopher D.

  公开号：US20090246808A1

  公开（公告）日：2009-10-01

  A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

  用于测定生物体液中分析物浓度的化学基质包括葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺。该化学基质与电化学生物传感器一起使用，以测定反应发生后分析器检测到的分析物浓度。使用葡萄糖脱氢酶、烟酰胺腺嘌呤二核苷酸、烷基苯并咪唑季铵盐和/或亚硝基苯胺的化学基质测定分析物浓度的方法是另一个方面的描述。该方法还特别具有五秒或更短的测试时间。利用新的化学基质的方法可以方便地测定分析物，例如血糖，在pH值约为6.5至约8.5的浓度范围内，浓度为约20-600 mg/dL。
• EP2265726B1
  申请人：——

  公开号：EP2265726B1

  公开（公告）日：2014-05-07
• COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION
  申请人：Roche Diabetes Care GmbH

  公开号：EP2823052B1

  公开（公告）日：2016-10-26
• STABILIZATION OF ENZYMES BY NICOTINIC ACID
  申请人：Roche Diabetes Care GmbH

  公开号：EP2994536B1

  公开（公告）日：2017-06-14