[(E)-[4-[(8S,11R,13S,14S,17S)-17-methoxy-17-(methoxymethyl)-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-11-yl]phenyl]methylideneamino] ethylsulfanylformate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(E)-[4-[(8S,11R,13S,14S,17S)-17-methoxy-17-(methoxymethyl)-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-11-yl]phenyl]methylideneamino] ethylsulfanylformate
• 化学式: C₃₁H₃₉NO₅S
• 分子量: 537.7
• InChiKey: OMIMSSSCELLLOS-BTKWMYLUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  99.5
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
  申请人：Bauzon Maxine

  公开号：US20070179113A1

  公开（公告）日：2007-08-02

  The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.
• Interferon-beta gene therapy using an improved, regulated expression system
  申请人：Bauzon Maxine

  公开号：US20080076729A1

  公开（公告）日：2008-03-27

  The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.
• NEW MODULATING MOLECULES FOR AN IMPROVED REGULATED EXPRESSION SYSTEM
  申请人：Bauzon Maxine

  公开号：US20110020925A1

  公开（公告）日：2011-01-27

  The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.
• [EN] INTERFERON-BETA GENE THERAPY USING AN IMPROVED, REGULATED EXPRESSION SYSTEM<br/>[FR] THÉRAPIE GÉNIQUE À INTERFÉRON BÊTA FAISANT APPEL À UN SYSTÈME D'EXPRESSION RÉGULÉE AMÉLIORÉ
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2007134906A1

  公开（公告）日：2007-11-29

  [EN] The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.
  [FR] La présente invention se rapporte à un système d'expression amélioré assurant l'expression régulée d'une molécule thérapeutique codée à protéine ou à acide nucléique dans les cellules d'un sujet, aux fins d'utilisation pour le traitement d'une maladie. En particulier, l'invention concerne un système d'expression génétique régulée amélioré, des compositions pharmaceutiques et des procédés d'utilisation associés destinés à traiter une maladie.
• [EN] GM-CSF GENE THERAPY FOR TREATMENT OF CROHN'S DISEASE USING AN IMPROVED REGULATED EXPRESSION SYSTEM<br/>[FR] THÉRAPIE GÉNIQUE PAR GM-CSF DESTINÉE À TRAITER LA MALADIE DE CROHN À L'AIDE D'UN SYSTÈME D'EXPRESSION RÉGULÉE AMÉLIORÉ
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2007134907A2

  公开（公告）日：2007-11-29

  [EN] The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease.
  [FR] La présente invention se rapporte à un système d'expression amélioré assurant l'expression régulée d'une molécule thérapeutique codée à protéine ou à acide nucléique dans les cellules d'un sujet, aux fins d'utilisation pour le traitement d'une maladie. En particulier, l'invention concerne un système d'expression génétique régulée amélioré, des compositions pharmaceutiques et des procédés d'utilisation associés destinés à traiter une maladie.