(R)-3-二甲氨基-3-苯基丙酸 | 94099-69-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: (R)-3-二甲氨基-3-苯基丙酸
• 英文名称: (R)-3-dimethylamino-3-phenylpropionic acid
• 英文别名: (R)-3-Dimethylamino-3-phenyl-propionsaeure；(3R)-3-(dimethylazaniumyl)-3-phenylpropanoate
• CAS: 94099-69-1
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: JTKDHNKYUPVADI-SNVBAGLBSA-N

物化性质

• 沸点：
  283.4±28.0 °C(Predicted)
• 密度：
  1.108±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2α,7β,9α,10β,13-pentaacetoxy-11β-hydroxy-5α-(3'-N,N-dimethylamino-3'-phenyl-propanoyloxy)taxa-4(20),12-diene 在 盐酸 作用下， 反应 1.0h， 生成 (R)-3-二甲氨基-3-苯基丙酸
  参考文献：
  名称：

  Bioactive Taxoids from Japanese Yew Taxus cuspidata and Taxol Biosynthesis

  摘要：

  A series of new taxoids, named taxuspines A similar to H and J similar to Z (1 similar to 25), have been isolated together with 37 known taxoids (26 similar to 62) including taxol (42) from the Japanese yew Taxus cuspidata Sieb. ct Zucc. These new taxoids possessed various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl2-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids as well as recent development of taxol biosynthesis.

  DOI：

  10.3987/rev-97-sr(n)7

文献信息

• Complement Pathway Modulators and Uses Thereof
  申请人：NOVARTIS AG

  公开号：US20150126492A1

  公开（公告）日：2015-05-07

  The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种I式化合物，一种制造该化合物的方法，以及其作为补体替代途径抑制剂的治疗用途，特别是作为抑制因子B的治疗用途，例如治疗与年龄相关的黄斑部病变和糖尿病视网膜病变。本发明还提供了药理活性剂的组合和制药组合物。
• Graf; Boeddeker, Justus Liebigs Annalen der Chemie, 1958, vol. 613, p. 111,115
  作者：Graf、Boeddeker

  DOI：——

  日期：——
• COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
  申请人：Novartis AG

  公开号：EP2864322B1

  公开（公告）日：2016-04-27
• US9452990B2
  申请人：——

  公开号：US9452990B2

  公开（公告）日：2016-09-27
• Bioactive Taxoids from Japanese Yew Taxus cuspidata and Taxol Biosynthesis
  作者：Jun'ichi Kobayashi、Hideyuki Shigemori

  DOI：10.3987/rev-97-sr(n)7

  日期：——

  A series of new taxoids, named taxuspines A similar to H and J similar to Z (1 similar to 25), have been isolated together with 37 known taxoids (26 similar to 62) including taxol (42) from the Japanese yew Taxus cuspidata Sieb. ct Zucc. These new taxoids possessed various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl2-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids as well as recent development of taxol biosynthesis.