(1-Amino-6-hydroxy-6-phosphonohexyl)phosphonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (1-Amino-6-hydroxy-6-phosphonohexyl)phosphonic acid
• 化学式: C₆H₁₇NO₇P₂
• 分子量: 277.15
• InChiKey: AJIOCUFDSIXHQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  161
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• PROCESS FOR TREATING LAMENESS BY ADMINISTRATION OF A BISPHOSPHONIC ACID DERIVATIVE
  申请人：——

  公开号：US20010006960A1

  公开（公告）日：2001-07-05

  The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula: 1 in which: R 1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C 1 -C 4 )alkylamino or a di(C 1 -C 4 )alkylamino; R 2 represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono(C 1 -C 4 )alkylamino or a di(C 1 -C 4 )alkylamino; a (C 3 -C 7 ) cycloalkylamino, or R 2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl, of one of its pharmaceutically acceptable salts or of one of its hydrates.

  本发明涉及一种治疗骨性、关节性或骨关节性跛足的方法，包括向人或未患关节炎或骨折的动物施用有效量的式（1）双膦酸衍生物： 1 其中 R 1 代表氢原子、卤素原子、羟基、氨基、单(C 1 -C 4 )烷基氨基或二(C 1 -C 4 )烷基氨基； R 2 代表卤素原子、由 1 至 5 个碳原子组成的线性烷基，该烷基未被取代或被选 自以下基团的基团取代：氯原子、羟基、氨基、单(C.1-C.4)烷基氨基、(C.1-C.4) 1 -C 4 )烷基氨基或二(C 1 -C 4)烷基氨基。 1 -C 4 )烷基氨基；一种(C 3 -C 7 )环烷基氨基、 或 R 2 代表苯氧基、苯基、硫醇、苯硫基、氯苯硫基、吡啶基、吡啶-甲基、1-吡啶-1-羟甲基、咪唑-甲基或 4-硫代吗啉基、 的一种药学上可接受的盐或其一种水合物。
• Process for increasing the egg production and strengthening the eggshells of poultry
  申请人：——

  公开号：US20030013685A1

  公开（公告）日：2003-01-16

  The present invention relates to a process for increasing the egg production and strengthening the eggshells of poultry, which comprises the administration to the animal of at least one bisphosphonic compound chosen from a bisphosphonic acid, a physiologically acceptable salt thereof, hydrates thereof and mixtures thereof.

  本发明涉及一种提高家禽产蛋量和增强蛋壳强度的工艺，包括向动物施用至少一种双膦化合物，该化合物选自双膦酸、其生理上可接受的盐、其水合物及其混合物。
• Process for treating lameness by administration of a bisphosphonic acid derivative
  申请人：Sanofi Sante Nutrition Animale

  公开号：US20030032627A1

  公开（公告）日：2003-02-13

  The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula: 1 in which: R 1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C 1 -C 4 )alkylamino or a di(C 1 -C 4 ) alkylamino; R 2 represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono (C 1 -C 4 ) alkylamino or a di(C 1 -C 4 ) alkylamino; a (C 3 -C 7 ) cycloalkylamino, or R 2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl, of one of its pharmaceutically acceptable salts or of one of its hydrates.

  本发明涉及一种治疗骨性、关节性或骨关节性跛足的方法，包括向人或未患关节炎或骨折的动物施用有效量的式（1）双膦酸衍生物： 1 其中 R 1 代表氢原子、卤素原子、羟基、氨基、单(C 1 -C 4 )烷基氨基或二(C 1 -C 4 )烷基氨基； R 2 代表卤素原子、由 1 至 5 个碳原子组成的线性烷基，该烷基未被取代或被选 自以下基团的基团取代：氯原子、羟基、氨基、单（C 1 -C 4 烷基氨基或二(C 1 -C 4 )烷基氨基；一种(C 3 -C 7 环烷基氨基、 或 R 2 代表苯氧基、苯基、硫醇、苯硫基、氯苯硫基、吡啶基、吡啶-甲基、1-吡啶-1-羟甲基、咪唑-甲基或 4-硫代吗啉基、 的一种药学上可接受的盐或其一种水合物。
• Process for treating lameness administration of a bisphosphonic acid derivative
  申请人：Ceva Sante Animale

  公开号：US20040110726A1

  公开（公告）日：2004-06-10

  The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula: 1 in which: R 1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C 1 -C 4 )alkylamino or a di (C 1 -C 4 ) alkylamino; R 2 represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono(C 1 -C 4 )alkylamino or a di (C 1 -C 4 )alkylamino; a (C 3 -C 7 ) cycloalkylamino, or R 2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl, of one of its pharmaceutically acceptable salts or of one of its hydrates.

  本发明涉及一种治疗骨性、关节性或骨关节性跛足的方法，包括向人或未患关节炎或骨折的动物施用有效量的式（1）双膦酸衍生物： 1 其中 R 1 代表氢原子、卤素原子、羟基、氨基、单(C 1 -C 4 )烷基氨基或二(C 1 -C 4 )烷基氨基； R 2 代表卤素原子、由 1 至 5 个碳原子组成的线性烷基，该烷基未被取代或被选 自以下基团的基团取代：氯原子、羟基、氨基、单(C 1 -C 4 )烷基氨基或二(C 1 -C 4 )烷基氨基；一种(C 3 -C 7 )环烷基氨基、 或 R 2 代表苯氧基、苯基、硫醇、苯硫基、氯苯硫基、吡啶基、吡啶-甲基、1-吡啶-1-羟甲基、咪唑-甲基或 4-硫代吗啉基、 的一种药学上可接受的盐或其一种水合物。
• Composition pharmaceutique pour administration orale à base d'un dérivé d'acide diphosphonique
  申请人：ELF SANOFI

  公开号：EP0336851B1

  公开（公告）日：1992-03-18