(4Z)-4-(quinolin-4-ylmethylidene)isoquinoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (4Z)-4-(quinolin-4-ylmethylidene)isoquinoline-1,3-dione
• 化学式: C₁₉H₁₂N₂O₂
• 分子量: 300.3
• InChiKey: DIJUMKYGKQGFGN-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cellular kinases involved in cytomegalovirus infection and their inhibition
  申请人：Axxima Pharmaceuticals Aktiengesellschaft

  公开号：EP1201765A2

  公开（公告）日：2002-05-02

  The role of certain cellular kinases active during Human Cytomegalovirus infection is disclosed. These cellular kinases are useful to detect HCMV infection, and can be used to screen for cellular kinase inhibitors. Cellular kinases inhibitors, which effectively downregulate these key cellular components, serve as effective therapeutics against HCMV infection.

  本研究揭示了人类巨细胞病毒感染期间活跃的某些细胞激酶的作用。这些细胞激酶有助于检测 HCMV 感染，并可用于筛选细胞激酶抑制剂。细胞激酶抑制剂能有效下调这些关键细胞成分，可作为抗 HCMV 感染的有效疗法。
• Cellular kinases involved in Cytomegalovirus infection and their inhibition
  申请人：——

  公开号：US20030082519A1

  公开（公告）日：2003-05-01

  The role of certain cellular kinases active during Human Cytomegalovirus infection is disclosed. These cellular kinases are useful to detect HCMV infection, and can be used to screen for cellular kinase inhibitors. Cellular kinases inhibitors, which effectively downregulate these key cellular components, serve as effective therapeutics against HCMV infection.

  本研究揭示了人类巨细胞病毒感染期间活跃的某些细胞激酶的作用。这些细胞激酶有助于检测 HCMV 感染，并可用于筛选细胞激酶抑制剂。细胞激酶抑制剂能有效下调这些关键细胞成分，可作为抗 HCMV 感染的有效疗法。
• US6849409B2
  申请人：——

  公开号：US6849409B2

  公开（公告）日：2005-02-01