1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol
• 英文别名: 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol；D-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol；N-(1-hydroxy-1-phenyl-3-pyrrolidin-1-ylpropan-2-yl)hexadecanamide
• 化学式: C₂₉H₅₀N₂O₂
• 分子量: 458.728
• InChiKey: JWTWRSVTLZQQAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  33
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] INHIBITION OF CANCER CELL MOTILITY<br/>[FR] INHIBITION DE LA MOTILITÉ DE CELLULES CANCÉREUSES
  申请人：UNIV NORTHWESTERN

  公开号：WO2016073897A1

  公开（公告）日：2016-05-12

  Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof) and one or more additional therapies (e.g., cancer therapies (e.g., hormone therapies and chemotherapies) are provided to inhibit cancer cell motility, inhibit metastasis, and/or treat cancer (e.g., prostate cancer, lung cancer, breast cancer, colon cancer, etc.).

  本文提供了用于抑制癌细胞运动性和/或转移的组合物和方法。在特定实施例中，提供了KBU2046（或其类似物）和一个或多个额外疗法（例如，癌症疗法（例如，激素疗法和化疗）），以抑制癌细胞的运动性，抑制转移，并/或治疗癌症（例如，前列腺癌，肺癌，乳腺癌，结肠癌等）。
• 4-EPI-ISOFAGOMINE DERIVATIVES
  申请人：Dorphan S.A.

  公开号：EP3088389A1

  公开（公告）日：2016-11-02

  The present invention relates to 4-epi-isofagomine derivatives, pharmaceutically acceptable salts thereof, and the use of said 4-epi-isofagomine derivatives in the treatment and/or prevention of lysosomal storage diseases. The present invention is furthermore related to processes for their preparation.

  本发明涉及4-epi-isofagomine衍生物、其药用可接受盐以及所述4-epi-isofagomine衍生物在溶酶体贮积病的治疗和/或预防中的使用。此外，本发明还涉及它们的制备方法。
• Amino ceramide-like compounds and therapeutic methods of use
  申请人：The Regents of The University of Michigan

  公开号：US20030073680A1

  公开（公告）日：2003-04-17

  The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

  本发明提供了一种氨基酰胺类似化合物，通过抑制酶GlyCer合成酶来抑制葡糖基酰胺（GlyCer）的形成，从而降低糖脂质的水平。本发明的化合物具有改进的GlcCer合成酶抑制活性，因此在治疗与改变的糖脂质水平相关的各种疾病和病症的治疗方法中是有用的。
• [EN] AMINO CERAMIDE-LIKE COMPOUNDS AND THERAPEUTIC METHODS OF USE<br/>[FR] COMPOSES DE TYPE AMINO-CERAMIDE ET PROCEDES THERAPEUTIQUES D'UTILISATION
  申请人：UNIV MICHIGAN

  公开号：WO2001004108A1

  公开（公告）日：2001-01-18

  Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

  提供了一种新型的氨基酸酰胺样化合物(1)，它们通过抑制酶GlcCer合成酶来抑制葡萄糖鞘脂(GlcCer)的形成，从而降低糖脂类物质的水平。本发明的化合物具有改良的GlcCer合成酶抑制活性，因此在治疗与改变糖脂类物质水平相关的各种疾病和病症的治疗方法中非常有用。
• Amino ceramide - like compounds and therapeutic methods of use
  申请人：——

  公开号：US20010041735A1

  公开（公告）日：2001-11-15

  Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

  本发明提供了一种新型氨基酸酰胺类化合物，可以通过抑制酶GlcCer合成酶来抑制葡萄糖鞘脂（GlcCer）的形成，从而降低糖脂类物质的水平。本发明的化合物具有改善的GlcCer合成酶抑制活性，因此在治疗与改变的糖脂类物质水平相关的各种疾病和症状的治疗方法中非常有用。