4-(4-Ethyl-1-benzothiophen-2-yl)-2,2-dimethylpiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 4-(4-Ethyl-1-benzothiophen-2-yl)-2,2-dimethylpiperidine
• 化学式: C₁₇H₂₃NS
• 分子量: 273.4
• InChiKey: FKXGSOJSBPRJJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• A PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF 2,2-DIALKYL-4-SUBSTITUTED PIPERIDINES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1242377A1

  公开（公告）日：2002-09-25
• [EN] A PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF 2,2-DIALKYL-4-SUBSTITUTED PIPERIDINES<br/>[FR] PROCEDE DESTINE A LA SYNTHESE STEREOSELECTIVE DE PIPERIDINES 2,2-DIALKYL-4-SUBSTITUEES
  申请人：LILLY CO ELI

  公开号：WO2001046142A1

  公开（公告）日：2001-06-28

  The present invention provides a process for preparing a compound of formula (I): wherein R?1 and R2¿ each independently represent C¿1?-C4 alkyl; and X represents an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II): wherein Q represents Cl or Br, with a suitable base followed by addition of a suitable Lewis acid and addition of a compound of formula R?-M+¿ wherein M+ is a suitable cation.