N-(4-Oxo-1-thiophen-3-ylmethyl-3,4-dihydro-phthalazin-6-yl)-propionamide | 497255-01-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-Oxo-1-thiophen-3-ylmethyl-3,4-dihydro-phthalazin-6-yl)-propionamide
• 英文别名: N-[4-oxo-1-(thiophen-3-ylmethyl)-3H-phthalazin-6-yl]propanamide
• CAS: 497255-01-3
• 化学式: C₁₆H₁₅N₃O₂S
• 分子量: 313.38
• InChiKey: GNEXSQUNTZMBEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  98.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
  申请人：PHARMACIA & UPJOHN S.p.A.

  公开号：US20030073692A1

  公开（公告）日：2003-04-17

  Compounds which are amino-phthalazinone derivatives and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

  本文揭示了一种氨基-邻苯二氮酮衍生物及其药学上可接受的盐，以及包含它们的制药组合物；这些化合物或组合物在治疗由于和/或与蛋白激酶活性改变有关的疾病方面具有用处，例如癌症、细胞增殖性疾病、阿尔茨海默病、病毒感染、自身免疫性疾病和神经退行性疾病。
• AMINO-PHTHALAZINONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1427708A1

  公开（公告）日：2004-06-16
• AMINO-PHTHALAZINONE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Pfizer Italia S.r.l.

  公开号：EP1427708B1

  公开（公告）日：2008-09-10
• US7432263B2
  申请人：——

  公开号：US7432263B2

  公开（公告）日：2008-10-07
• [EN] AMINO-PHTHALAZINONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES D'AMINO-PHTALAZINONE ACTIFS COMME INHIBITEURS DE KINASE, PROCESSUS DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERIVES
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003014090A1

  公开（公告）日：2003-02-20

  Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, togetherwith pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer'sdisease, viral infections, autoimmune diseases and neurodegenerative disorders.