(S)-1-环己基-3-甲基哌嗪 | 1187930-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: (S)-1-环己基-3-甲基哌嗪
• 英文名称: 4-cyclohexyl-2-(S)-methylpiperazine
• 英文别名: (S)-1-Cyclohexyl-3-methylpiperazine；(3S)-1-cyclohexyl-3-methylpiperazine
• CAS: 1187930-87-5
• 化学式: C₁₁H₂₂N₂
• 分子量: 182.309
• InChiKey: NZVWAQIJRNKNOB-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二乙基氰化铝 、 4-(4-methoxyphenylsulfanyl)benzaldehyde 、 (S)-1-环己基-3-甲基哌嗪 在 titanium(IV) isopropylate 作用下， 生成
  参考文献：
  名称：

  Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands

  摘要：

  A novel series of 2-(R)-methyl-substituted piperazines (e.g.. 2) is described. They are potent M-2 selective ligands that have > 100-fold selectivity versus the M-1 receptor. In the rat microdialysis assay. compound 14 showed significantly enhanced levels of acetylcholine after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00023-9

文献信息

• Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands
  作者：Joseph A Kozlowski、Guowei Zhou、Jayaram R Tagat、Sue-Ing Lin、Stuart W McCombie、Vilma B Ruperto、Ruth A Duffy、Robert A McQuade、Gordon Crosby、Lisa A Taylor、William Billard、Herbert Binch、Jean E Lachowicz

  DOI：10.1016/s0960-894x(02)00023-9

  日期：2002.3

  A novel series of 2-(R)-methyl-substituted piperazines (e.g.. 2) is described. They are potent M-2 selective ligands that have > 100-fold selectivity versus the M-1 receptor. In the rat microdialysis assay. compound 14 showed significantly enhanced levels of acetylcholine after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.