6-[1-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)ethenyl]pyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-[1-(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)ethenyl]pyridine-3-carboxylic acid
• 化学式: C₂₂H₂₅NO₂
• 分子量: 335.4
• InChiKey: DDGWTCVFQWFIAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• EXPANSION OF RENEWABLE STEM CELL POPULATIONS
  申请人：Gamida-Cell Ltd.

  公开号：US20160097037A1

  公开（公告）日：2016-04-07

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  离体和体内扩增可再生干细胞的方法，扩增的可再生干细胞群体及其用途。
• Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
  申请人：Boehm F. Marcus

  公开号：US20060106072A1

  公开（公告）日：2006-05-18

  Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass of Retinoic Acid Receptors (RARs). Examples of such compounds are bicyclic benzyl, pyridinyl, thiophene, furanyl, and pyrrole derivatives. The disclosed methods employ compounds for modulating processes selectively mediated by Retinoid X Receptors.

  本发明涉及利用类视黄醇化合物调节由视黄酸X受体介导的过程的复合物、组合物和方法，其中这些类视黄醇化合物具有对视黄酸X受体亚类（RXRs）的选择性活性，而不是对视黄酸受体亚类（RARs）的选择性活性。此类化合物的例子包括双环苄基、吡啶基、噻吩基、呋喃基和吡咯基衍生物。所披露的方法利用这些化合物来调节由视黄酸X受体选择性介导的过程。
• Expansion of renewable stem cell populations
  申请人：Peled Tony

  公开号：US20050008624A1

  公开（公告）日：2005-01-13

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  可再生干细胞的离体和体内扩增方法，扩增的可再生干细胞群体及其用途。
• Expansion Of Renewable Stem Cell Populations
  申请人：Peled Tony

  公开号：US20110033427A1

  公开（公告）日：2011-02-10

  Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

  可再生干细胞的离体和体内扩增方法、可再生干细胞扩增群体及其用途。
• Espansion of renewable stem cell populations
  申请人：Gamida Cell Ltd.

  公开号：EP2206773A1

  公开（公告）日：2010-07-14

  The present invention relates to a method of expanding a population of CD34+ hematopoietic stem cells ex-vivo, while at the same time, inhibiting differentiation of the stem cells ex-vivo, the method comprising: (a) culturing said CD34+ hematopoietic stem cells ex-vivo under conditions allowing for cell proliferation, said conditions which comprise providing nutrients, serum and a combination of cytokines including stem cell factor, thrombopoietin, FLt3 ligand, IL-6 and IL-3, and (b) in the same culture medium providing nicotinamide in an amount between 1.0 mM to 10 mM, wherein said cells are cultured for a culture period resulting in expanding the population of CD34+ hematopoietic stem cells while inhibiting differentiation of said CD34+ hematopoietic stem cells ex-vivo to produce an expanded CD34+ hematopoietic stem cell population with an increased proportion of CD34+/Lin- and CD34+/CD38- cells in the expanded culture as compared to CD34+ cells cultured in the presence of cytokines and nutrients without exogenously added nicotinamide.

  本发明涉及一种体内外扩增CD34+造血干细胞群体，同时抑制体内外干细胞分化的方法，该方法包括：(a) 在允许细胞增殖的条件下体内外培养所述 CD34+造血干细胞，所述条件包括提供营养物质、血清和细胞因子组合，包括干细胞因子、血小板生成素、FLt3 配体、IL-6 和 IL-3，以及 (b) 在相同的培养基中提供烟酰胺，其量在 1.0 mM 至 10 mM，其中所述细胞培养一段培养期，导致扩大 CD34+ 造血干细胞群，同时抑制所述 CD34+ 造血干细胞的体外分化，以产生扩大的 CD34+ 造血干细胞群，与在细胞因子和营养物质存在下培养的不外源添加烟酰胺的 CD34+ 细胞相比，扩大的培养物中 CD34+/Lin- 和 CD34+/CD38- 细胞比例增加。