N-(1H-indazol-5-yl)-2-phenylquinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(1H-indazol-5-yl)-2-phenylquinazolin-4-amine
• 化学式: C₂₁H₁₅N₅
• 分子量: 337.4
• InChiKey: IMHCQIITORSJKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF
  申请人：BANKSTON Donald

  公开号：US20100125139A1

  公开（公告）日：2010-05-20

  A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.

  一种制备多种喹唑啉化合物的方法，这些化合物可用作Rho激酶抑制剂，因此在治疗高血压和其他适应症方面具有用途。
• RHO-KINASE INHIBITORS
  申请人：Nagarathnam Dhanaphalan

  公开号：US20100137324A1

  公开（公告）日：2010-06-03

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明揭示了化合物及其衍生物，它们的合成以及它们作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症，例如冠心病，是有用的。
• Process for preparing quinazoline RHO-kinase inhibitors and intermediates thereof
  申请人：BAYER CORPORATION

  公开号：EP1953152A1

  公开（公告）日：2008-08-06

  The present invention relates to methods of producing quinazoline compounds and derivatives thereof which are useful as Rho-kinase Inhibitors or intermediates thereof. Rho-kinase inhibitors are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明涉及生产可用作Rho-激酶抑制剂或其中间体的喹唑啉化合物及其衍生物的方法。Rho-激酶抑制剂可用于抑制肿瘤生长、治疗勃起功能障碍和治疗由Rho-激酶介导的其他适应症，如冠心病。
• US7645878B2
  申请人：——

  公开号：US7645878B2

  公开（公告）日：2010-01-12