6-[2-hydroxy-2-(4-chlorophenyl)ethyl]-2,4-di-N-pyrrolidinylpyrimidine | 254964-30-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-[2-hydroxy-2-(4-chlorophenyl)ethyl]-2,4-di-N-pyrrolidinylpyrimidine
• 英文别名: 1-(4-Chlorophenyl)-2-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)ethanol
• CAS: 254964-30-2
• 化学式: C₂₀H₂₅ClN₄O
• 分子量: 372.898
• InChiKey: HMYPLGBZNMDQMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• EP1095026A4
  申请人：——

  公开号：EP1095026A4

  公开（公告）日：2001-10-31
• PHARMACEUTICAL AGENTS
  申请人：MONASH UNIVERSITY

  公开号：EP1095026A1

  公开（公告）日：2001-05-02
• US6881740B1
  申请人：——

  公开号：US6881740B1

  公开（公告）日：2005-04-19
• [EN] PHARMACEUTICAL AGENTS<br/>[FR] AGENTS PHARMACEUTIQUES
  申请人：UNIV MONASH

  公开号：WO2000002865A1

  公开（公告）日：2000-01-20

  This invention relates to compounds of formula (1) wherein B is optionally substituted aryl; R?1 and R2¿ are the same or different and are independently selected from hydrogen or C¿1-3? alkyl; n is 1 or 2, preferably n is 1; m is 0 or 1; R?3¿ is hydrogen or acyl; R?4 and R5¿ are the same or different and are independently selected from amino, alkylamino, dialkylamino, arylamino and C¿2?-C8 cycloalkylamino; X and Y are independently selected from C, H or N provided at least one of X and Y is N; and salts thereof, solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof and/or isomers thereof; and processes for their preparation and methods of treatment, pharmaceutical formulations and uses involving them.