N-[(1R,2S)-2-(3,4-dihydro-2(1H)-isoquinolinyl)-1,2-dihydro-1-naphthalenyl]-4-methylbenzenesulfonamide | 337376-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-[(1R,2S)-2-(3,4-dihydro-2(1H)-isoquinolinyl)-1,2-dihydro-1-naphthalenyl]-4-methylbenzenesulfonamide
• 英文别名: N-[(1R,2S)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-1,2-dihydronaphthalen-1-yl]-4-methylbenzenesulfonamide
• CAS: 337376-95-1
• 化学式: C₂₆H₂₆N₂O₂S
• 分子量: 430.571
• InChiKey: BRZJQWUGBCALQM-IZZNHLLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel compounds and a novel process for their preparation
  申请人：Fagnou Keith

  公开号：US20050014721A1

  公开（公告）日：2005-01-20

  The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.

  本发明涉及一种制备含有氢化萘环结构的对映体富集化合物的方法。该过程涉及使用铑作为催化剂，并在膦配体的存在下，将氧化苯并[2,3-c]环辛二烯与亲核试剂反应。合成的化合物可用于制备治疗各种疾病和病况的药物制剂。
• Novel hydronaphthalene compounds, prepared by a rhodium catalysed ring opening reaction in the presence of phosphine ligand
  申请人：AstraZeneca AB

  公开号：EP1498406A1

  公开（公告）日：2005-01-19

  The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.

  本发明涉及一种含有氢萘环结构的对映体富集化合物的制造工艺。该过程包括使用铑作为催化剂，在膦配体存在的情况下，使氧杂苯并降冰片二烯与亲核物反应。合成的化合物可用于治疗各种疾病和病症的药物制剂中。
• NOVEL HYDRONAPHTHALENE COMPOUNDS, PREPARED BY A RHODIUM CATALYZED RING OPENING REACTION IN THE PRESENCE OF PHOSPHINE LIGAND
  申请人：AstraZeneca AB

  公开号：EP1228024B1

  公开（公告）日：2004-09-01
• US6525068B1
  申请人：——

  公开号：US6525068B1

  公开（公告）日：2003-02-25
• US6784210B2
  申请人：——

  公开号：US6784210B2

  公开（公告）日：2004-08-31