N-(1-benzylindazol-5-yl)-6-[(2-methylsulfonylethylamino)methyl]quinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(1-benzylindazol-5-yl)-6-[(2-methylsulfonylethylamino)methyl]quinazolin-4-amine
• 化学式: C₂₆H₂₆N₆O₂S
• 分子量: 486.6
• InChiKey: JZTWORKNAGLZGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE<br/>[FR] MODULATEURS DE LA VOIE DES RÉCEPTEURS DU FACTEUR DE CROISSANCE ÉPIDERMIQUE (EGFR) POUR UTILISATION DANS LE TRAITEMENT OU LA PRÉVENTION DE LA CONSOMMATION EXCESSIVE D'ALCOOL OU D'AUTRES DROGUES
  申请人：UNIV CALIFORNIA

  公开号：WO2009070328A1

  公开（公告）日：2009-06-04

  The present invention provides methods of using modulators of the epidermal growth factor receptor (EGFR) pathway for treatment or prevention of substance abuse such as alcohol abuse. The modulators include small molecule inhibitors such as Erlotinib (TARCEVA®, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- quinazolineamine) or a pharmaceutically acceptable salt, hydrate or prodrug thereof and Gefitinib [IRES S A®, N-(3 -chloro-4-fluoro-phenyl)-7-methoxy-6-(3 -morpholin-4- ylpropoxy)quinazolin-4-amine] or a pharmaceutically acceptable salt, hydrate or prodrug thereof and various macromolecular inhibitors of the EGFR pathway such as siRNAs and antibodies that target genes or proteins in the EGFR/ERK pathway such as one of the EGFR/ErbB protein or a homolog thereof.