(R,S)-2-mercaptomethyl-2,3-dihydro-5H-thiazolo[2,3-b]chinazolin-5-one | 363178-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (R,S)-2-mercaptomethyl-2,3-dihydro-5H-thiazolo[2,3-b]chinazolin-5-one
• 英文别名: 2-(Sulfanylmethyl)-2,3-dihydro-[1,3]thiazolo[2,3-b]quinazolin-5-one
• CAS: 363178-78-3
• 化学式: C₁₁H₁₀N₂OS₂
• 分子量: 250.345
• InChiKey: DGJZLWBUAZPIGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [Amino-[(5-oxo-2,3-dihydro-[1,3]thiazolo[2,3-b]quinazolin-2-yl)methylsulfanyl]methylidene]azanium;bromide 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以74%的产率得到(R,S)-2-mercaptomethyl-2,3-dihydro-5H-thiazolo[2,3-b]chinazolin-5-one
  参考文献：
  名称：

  TRICYCLISCHE MERCAPTOMETHYLSUBSTITUIERTE 2,3-DIHYDRO-CHINAZOLIN-5-ONE UND 2,3-DIHYDRO-BENZO-[1,2,4]-THIADIAZIN-5,5-DIOXIDE ALS MATRIX METALLOPROTEINASE (MMP) INHIBITOREN

  摘要：

  公开号：

  EP1319010B1

文献信息

• Method for cleaving the human growth hormone gh
  申请人：——

  公开号：US20040259192A1

  公开（公告）日：2004-12-23

  The invention relates to a method for cleaving human growth hormone GH by means of matrix metalloproteinase MMP. It has been found that MMP-3 cleaves the growth hormone into two fragments, the 16 kDa fragment of which is stable. The invention solves the problem of providing means which positively influence both tumor growth, proliferative diabetic retinopathy and others as well as angiogenesis, in particular on treatment the cardiac infarction, retarded wound healing, menstrual cycle disturbances and others, by means of regulation of the human growth hormone.

  本发明涉及一种通过基质金属蛋白酶 MMP 来裂解人类生长激素 GH 的方法。研究发现，MMP-3 能将生长激素裂解成两个片段，其中 16 kDa 的片段是稳定的。本发明解决了提供通过调节人类生长激素对肿瘤生长、增殖性糖尿病视网膜病变等以及血管生成产生积极影响的方法的问题，特别是在治疗心肌梗塞、伤口愈合迟缓、月经周期紊乱等方面。
• Tricylic mercaptomethyl-substituted 2,3-dihydro-quinazolin-5-ones and 2,3-dihydro-benzo-[1,2,4]-thiadiazin-5,5-dioxides as matrix metalloproteinase (MMP) inhibitors
  申请人：——

  公开号：US20040023953A1

  公开（公告）日：2004-02-05

  The invention relates to mercaptomethyl-substituted thiazolo[2,3-b]quinazolines, oxazolo[2,3-b]quinazolines and imidazolo[2,1-b]quinazolines. It is the object of the invention to discover new matrix metalloproteinase inhibitors (MMP) and give a simple synthesis method. The object is achieved by the production of the indicated compounds. By means of them it is possible to achieve progress using them as active substances in pharmaceutical preparations for treating diseases such as inflammatory responses of non-specific causes, sunburn and allergies.