(E,E)-2-(β-ethanolaminocarbonyl)-3-(3,5-dimethoxy-4-hydroxystyryl)acrylonitrile | 368836-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E,E)-2-(β-ethanolaminocarbonyl)-3-(3,5-dimethoxy-4-hydroxystyryl)acrylonitrile
• 英文别名: (2E,4E)-2-cyano-5-(4-hydroxy-3,5-dimethoxyphenyl)-N-(2-hydroxyethyl)penta-2,4-dienamide
• CAS: 368836-90-2
• 化学式: C₁₆H₁₈N₂O₅
• 分子量: 318.329
• InChiKey: IIHYSQAAVIPBIK-ZDHPXMGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION<br/>[FR] NOUVEAUX COMPOSES POUR LA MODULATION DE LA PROLIFERATION CELLULAIRE
  申请人：HSC RES DEV LP

  公开号：WO2005092904A1

  公开（公告）日：2005-10-06

  Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

  新型的苯乙烯丙烯腈化合物被揭示，这些化合物在治疗各种细胞增殖性疾病，如癌症方面具有用处。
• Novel Compounds for Modulating Cell Proliferation
  申请人：Roifman M. Chaim

  公开号：US20070243612A1

  公开（公告）日：2007-10-18

  Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

  本发明揭示了一种新型的苯乙烯腈化合物，可用于治疗多种细胞增殖性疾病，如癌症。
• Compounds for modulating cell proliferation
  申请人：HSC Research and Development Limited Partnership

  公开号：EP1752446A2

  公开（公告）日：2007-02-14

  Novel styrylacrylonitrile compounds and a pharmaceutical composition comprising a compound of Formula II or a salt, solvate, or hydrate thereof: wherein R1 and R2 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, O-Si(C1-6alkyl)(C1-6alkyl)(C1-6alkyl), NO2, CF3, OCF3 and halo; R3 is selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, O-Si(C1-6alkyl)(C1-6alkyl)(C1-6alkyl), NO2, halo and CH2-S-(CH2)n Ar; Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents, independently selected from OH, C1-6alkyl, C1-6alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3 and halo; R6 is selected from Ar, OH and OC1-6alkyl; X is selected from O and S; n is 0-4; and p is 1-4, and conventional esters thereof formed with available hydroxy, amino or carboxyl groups. The pharmaceutical composition is useful in treating a variety of cell proliferative disorders such as cancer.

  新型苯乙烯-丙烯腈化合物和包含式 II 化合物或其盐、溶液或水合物的药物组合物： 其中 R1 和 R2 各自独立地选自 H、OH、C1-6烷基、C1-6烷氧基、NH2、NH-C1-6烷基、N(C1-6烷基)(C1-6烷基)、SH、S-C1-6烷基、O-Si(C1-6烷基)(C1-6烷基)(C1-6烷基)、NO2、CF3、OCF3 和卤素；R3 选自 H、OH、C1-6烷基、C1-6烷氧基、NH2、NH-C1-6烷基、N(C1-6烷基)(C1-6烷基)、SH、S-C1-6烷基、O-Si(C1-6烷基)(C1-6烷基)(C1-6烷基)、NO2、卤素和 CH2-S-(CH2)n Ar；R6 选自 Ar、OH 和 OC1-6烷基；X 选自 O 和 S；n 为 0-4；p 为 1-4，以及其与可用的羟基、氨基或羧基形成的常规酯。该药物组合物可用于治疗各种细胞增殖性疾病，如癌症。
• COMPOUNDS FOR MODULATING CELL PROLIFERATION
  申请人：HSC Research and Development Limited Partnership

  公开号：EP1272457B1

  公开（公告）日：2006-08-23
• NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION
  申请人：HSC Research and Development Limited Partnership

  公开号：EP1727822A1

  公开（公告）日：2006-12-06