3-(10h-Phenoxazin-10-yl)-propane-1-sulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 3-(10h-Phenoxazin-10-yl)-propane-1-sulfonic acid
• 英文别名: 3-phenoxazin-10-ylpropane-1-sulfonic acid
• 化学式: C₁₅H₁₅NO₄S
• 分子量: 305.4
• InChiKey: ILKRVWPSIBCNIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds for generating chemiluminescence with a peroxidase
  申请人：——

  公开号：US20030170762A1

  公开（公告）日：2003-09-11

  Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.

  披露了包含C-C双键的全新化合物，其中一个碳原子上带有两个含硫原子的基团。这些化合物在通过与过氧化物酶酶和过氧化物反应来快速产生化学发光的方法和组合物中有用。由此产生的化学发光可用作检测过氧化物酶或产过氧化物酶的酶的检测信号，以及在利用酶标记的特定结合对进行的分析中。
• Acridane-9-dithiocarboxylate derivatives for generating chemiluminescence with a peroxidase
  申请人：LUMIGEN, INC.

  公开号：EP2096110A1

  公开（公告）日：2009-09-02

  Novel compounds comprising a C-C double bound substituted at one carbon with two sulphur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detactable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.

  本发明公开了由一个碳上被两个含硫原子基团取代的 C-C 双键组成的新型化合物。这些化合物适用于通过与过氧化物酶和过氧化物反应快速产生化学发光的方法和组合物。由此产生的化学发光可在过氧化物酶或产生过氧化物的酶的检测中以及在采用酶标记的特异性结合对的检测中用作可检测信号。
• CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE WITH EXTENDED SHELF-LIFE
  申请人：Cyanagen Srl

  公开号：EP3855185A1

  公开（公告）日：2021-07-28

  A kit for performing an assay for determining an analyte in a sample with an extended shelf-life, wherein the kit comprises a chemiluminescent cyclic dihydrazide, an enhancer, a co-enhancer, and a peroxide oxidizer. The kit is useful in blot assays and immunoassays for the detection of proteins and nucleic acid molecules.

  一种用于测定样品中分析物的试剂盒，可延长保质期，其中试剂盒包括化学发光环二肼、增强剂、共增强剂和过氧化物氧化剂。该试剂盒适用于检测蛋白质和核酸分子的印迹分析和免疫分析。
• Solution phase homogeneous assays
  申请人：Beckman Coulter, Inc.

  公开号：US10036708B2

  公开（公告）日：2018-07-31

  Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator is brought into reactive configuration with a chemiluminescent compound to activates it. The sample is also treated with an agent to reduce signal not related to analyte. Finally, the sample is treated with a trigger solution thereby producing light from the activated chemiluminescent compound. No reagents are associated with a surface or other solid phase.

  本发明公开了用于测定疑似含有分析物的样品中分析物的方法、试剂、试剂盒和系统，其中所有试剂均可溶于水溶液。一种检测方法包括处理疑似含有被分析物的样品，如果样品中存在被分析物，则将活化剂与化学发光化合物反应配置，使其活化。还用一种药剂处理样品，以减少与分析物无关的信号。最后，用触发溶液处理样品，从而使活化的化学发光化合物发光。试剂与表面或其他固相无关。
• Assay methods using chemiluminescent detection of peroxidase
  申请人：Akhavan-Tafti Hashem

  公开号：US20050158815A1

  公开（公告）日：2005-07-21

  Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs. Use of the methods provides rapid signal generation, achieving a plateau intensity in under one minute. The substrate can be provided in a composition which demonstrates unexpectedly long storage stability.

  本发明公开了至少一种由一个碳上被两个含硫原子基团取代的 C-C 双键组成的化合物与过氧化物酶和过氧化物反应而迅速产生化学发光的方法。由此产生的化学发光可在过氧化物酶或产生过氧化物的酶的检测中以及在采用酶标记的特异性结合对的检测中用作可检测的信号。使用这些方法可以快速产生信号，在一分钟内达到高原强度。底物可以以组合物的形式提供，这种组合物具有出乎意料的长期储存稳定性。