1-cyclopropyl-6-fluoro-7-(6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-cyclopropyl-6-fluoro-7-(6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid
• 英文别名: 1-Cyclopropyl-6-fluoro-7-(6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 化学式: C₂₀H₁₈FN₃O₃S
• 分子量: 399.446
• InChiKey: OYKXMIZMARZYKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Quinoline and naphthyridine carboxylic acid antibacterials
  申请人：——

  公开号：US20020049223A1

  公开（公告）日：2002-04-25

  Compounds having formula (I) 1 or pharmaceutically acceptable salts or prodrugs thereof, are useful as antibacterial agents.

  具有化学式(I)1的化合物或其药用可接受的盐或前药，可用作抗菌剂。
• QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS
  申请人：ABBOTT LABORATORIES

  公开号：EP1226146A2

  公开（公告）日：2002-07-31
• [EN] QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS<br/>[FR] ANTIBACTERIENS A BASE D'ACIDE QUINOLINE CARBOXYLIQUE ET D'ACIDE NAPHTHYRIDINE CARBOXYLIQUE
  申请人：ABBOTT LAB

  公开号：WO2001032655A2

  公开（公告）日：2001-05-10

  Compounds having formula (I), or pharmaceutically acceptable salts or prodrugs thereof, wherein A1 is nitrogen or (II), wherein W is selected from the group consisting of (1) hydrogen and (2) optionally substituted alkyl; A2 is selected from the group consisting of (1) -S-, (2) -O-, and (3) -N(R7)-, wherein R7 is hydrogen or C¿1?-C6 alkyl; and R?5 and R6¿ together are a carbocyclic or a heterocyclic ring, are useful as antibacterial agents.