(Z)-3-(二(2-羟基乙基)氨基)-2-(2-羟基乙基-(羟基甲基)氨基)丙-2-烯-1-醇 | 77044-78-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (Z)-3-(二(2-羟基乙基)氨基)-2-(2-羟基乙基-(羟基甲基)氨基)丙-2-烯-1-醇
• 英文名称: Forcide 78
• 英文别名: (Z)-3-[bis(2-hydroxyethyl)amino]-2-[2-hydroxyethyl(hydroxymethyl)amino]prop-2-en-1-ol
• CAS: 77044-78-1
• 化学式: C₁₀H₂₂N₂O₅
• 分子量: 250.29
• InChiKey: CPHKJTZJSGQUER-YFHOEESVSA-N

物化性质

• 沸点：
  536.1±50.0 °C(Predicted)
• 密度：
  1.323±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  108
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Cosmetic preservatives as therapeutic corneoscleral tissue cross-linking agents
  申请人：Paik David Choohyun

  公开号：US10105350B2

  公开（公告）日：2018-10-23

  A method of cross-linking collagen present in a collagenous tissue comprising contacting the collagenous tissue with an amount of a formaldehyde releasing agent effective to crosslink the collagen is provided. A method of inhibiting loss of structural integrity of a collagenous tissue during transplantation-related transport comprising contacting the collagenous tissue with an amount of a formaldehyde releasing agent effective to inhibit loss of structural integrity of the collagenous tissue is also provided. A composition for ophthalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and ophthalmically suitable carriers or excipients is also provided. Finally, a method of altering the refractive power of a cornea comprising contacting the cornea with a formaldehyde releasing agent so as to effect cross-linking in the cornea and thereby alter the refractive power of the cornea is provided.

  本发明提供了一种交联存在于胶原组织中的胶原蛋白的方法，包括将胶原组织与一定量的甲醛释放剂接触，以有效交联胶原蛋白。还提供了一种抑制胶原组织在移植相关运输过程中丧失结构完整性的方法，该方法包括将胶原组织与一定量的甲醛释放剂接触，甲醛释放剂能有效抑制胶原组织丧失结构完整性。还提供了一种用于眼科用药的组合物，该组合物由甲醛释放剂、碳酸氢钠和眼科适用的载体或赋形剂组成。最后，还提供了一种改变角膜屈光力的方法，该方法包括将角膜与甲醛释放剂接触，使角膜发生交联，从而改变角膜的屈光力。
• Compositions comprising corneoscleral tissue cross-linking agents
  申请人：Paik David Choohyun

  公开号：US10292967B2

  公开（公告）日：2019-05-21

  A composition for opththalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and an ophthalmically suitable carrier or excipient is provided.

  提供了一种用于眼科用药的组合物，其中包含甲醛释放剂、碳酸氢钠和眼科适用的载体或赋形剂。
• COSMETIC PRESERVATIVES AS THERAPEUTIC CORNEOSCLERAL TISSUE CROSS-LINKING AGENTS
  申请人：Paik David Choohyun

  公开号：US20160374992A1

  公开（公告）日：2016-12-29

  A method of cross-linking collagen present in a collagenous tissue comprising contacting the collagenous tissue with an amount of a formaldehyde releasing agent effective to crosslink the collagen is provided. A method of inhibiting loss of structural integrity of a collagenous tissue during transplantation-related transport comprising contacting the collagenous tissue with an amount of a formaldehyde releasing agent effective to inhibit loss of structural integrity of the collagenous tissue is also provided. A composition for ophthalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and ophthalmically suitable carriers or excipients is also provided. Finally, a method of altering the refractive power of a cornea comprising contacting the cornea with a formaldehyde releasing agent so as to effect cross-linking in the cornea and thereby alter the refractive power of the cornea is provided.
• COMPOSITIONS COMPRISING CORNEOSCLERAL TISSUE CROSS-LINKING AGENTS
  申请人：Paik David Choohyun

  公开号：US20190015388A1

  公开（公告）日：2019-01-17

  A composition for opththalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and an ophthalmically suitable carrier or excipient is provided.