2-methyl-5-[(E)-2-nitroprop-1-enyl]-1,3-benzoxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-methyl-5-[(E)-2-nitroprop-1-enyl]-1,3-benzoxazole
• 化学式: C11H10N2O3
• 分子量: 218.21
• InChiKey: BYZBORIGPXLEKO-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ANTIMICROBIAL AND RADIOPROTECTIVE COMPOUNDS
  申请人：BioDiem, Ltd

  公开号：US20150258059A1

  公开（公告）日：2015-09-17

  The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R 1 to R 5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R 6 and R 7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R 6 and R 7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

  本发明涉及一种治疗和/或预防微生物感染的方法，包括给予化合物（I）的有效量，其中X和Y可以相同也可以不同，并且选自杂原子；根据杂原子X和Y，是双键或单键；R1至R5可以相同也可以不同，并且选自氢或非有害取代基；R6和R7可以相同也可以不同，并且选自氢和非有害取代基，或者当存在双键时，R6和R7中的一个可以缺失；药学上可接受的盐或衍生物，前药，互变异构体和/或同分异构体。本发明还涉及一种保护受试者免受辐射损伤的方法，一种癌症放射治疗方法以及将上述化合物（I）用作抗微生物或放射防护剂的用途。化合物（I）的一些是新颖的，在本发明中也有描述，以及含有它们的药用或兽用组合物。
• Nitro-styrene derivatives having antimicrobial activity
  申请人：Biodiem Ltd.

  公开号：EP2471531A2

  公开（公告）日：2012-07-04

  The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R1 to R5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R6 and R7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R6 and R7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

  本发明涉及一种治疗和/或预防微生物感染的方法，包括给药有效量的式(I)化合物的步骤，其中X和Y相同或不同，选自杂原子；根据杂原子X和Y的不同，是双键或单键；R1至R5相同或不同，且选自氢或非易脱色取代基；以及R6和R7相同或不同，且选自氢或非易脱色取代基，或当存在双键时，R6和R7中的一个不存在，药学上可接受的盐或衍生物、原药、同分异构体和/或异构体。本发明还涉及一种保护受试者免受辐射损伤的方法、一种癌症放疗的方法以及将上文所定义的式(I)化合物用作抗菌剂或辐射保护剂。本发明还描述了一些新颖的式 (I) 化合物以及含有这些化合物的药物或兽药组合物。
• Nitrostyrenederivatives with antimicrobial action
  申请人：Biodiem Ltd.

  公开号：EP2468275A1

  公开（公告）日：2012-06-27

  The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R1 to R5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R6 and R7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R6 and R7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

  本发明涉及一种治疗和/或预防微生物感染的方法，包括给药有效量的式(I)化合物的步骤，其中X和Y相同或不同，选自杂原子；根据杂原子X和Y的不同，是双键或单键；R1至R5相同或不同，且选自氢或非易脱色取代基；以及R6和R7相同或不同，且选自氢或非易脱色取代基，或当存在双键时，R6和R7中的一个不存在，药学上可接受的盐或衍生物、原药、同分异构体和/或异构体。本发明还涉及一种保护受试者免受辐射损伤的方法、一种癌症放疗的方法以及将上文所定义的式(I)化合物用作抗菌剂或辐射保护剂。本发明还描述了一些新颖的式 (I) 化合物以及含有这些化合物的药物或兽药组合物。
• Nitrostyrene derivatives having antimicrobial action
  申请人：Biodiem Ltd.

  公开号：EP2468276A1

  公开（公告）日：2012-06-27

  The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R1 to R5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R6 and R7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R6 and R7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

  本发明涉及一种治疗和/或预防微生物感染的方法，包括给药有效量的式(I)化合物的步骤，其中X和Y相同或不同，选自杂原子；根据杂原子X和Y的不同，是双键或单键；R1至R5相同或不同，且选自氢或非易脱色取代基；以及R6和R7相同或不同，且选自氢或非易脱色取代基，或当存在双键时，R6和R7中的一个不存在，药学上可接受的盐或衍生物、原药、同分异构体和/或异构体。本发明还涉及一种保护受试者免受辐射损伤的方法、一种癌症放疗的方法以及将上文所定义的式(I)化合物用作抗菌剂或辐射保护剂。本发明还描述了一些新颖的式 (I) 化合物以及含有这些化合物的药物或兽药组合物。
• ANTMICROBIAL AND RADIOPROTECTIVE COMPOUNDS
  申请人：Denisenko Peter Prokofievich

  公开号：US20090012137A1

  公开（公告）日：2009-01-08

  The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R 1 to R 5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R 6 and R 7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R 6 and R 7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and/or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.