1-[2-(2-Thiophen-2-yl-2-adamantyl)ethyl]pyrrolidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[2-(2-Thiophen-2-yl-2-adamantyl)ethyl]pyrrolidine
• 化学式: C₂₀H₂₉NS
• 分子量: 315.5
• InChiKey: CDRUKMHQAQKBEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION
  申请人：VERNALIS RESEARCH LIMITED

  公开号：EP1305306A2

  公开（公告）日：2003-05-02
• [EN] 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION<br/>[FR] NOUVELLES 2-ADAMANTYLETHYLAMINES ET LEUR UTILISATION DANS LE TRAITEMENT D'ETATS GENERALEMENT ASSOCIES A DES ANOMALIES DE LA TRANSMISSION GLUTAMATERGIQUE
  申请人：VERNALIS RES LTD

  公开号：WO2002008219A2

  公开（公告）日：2002-01-31

  The use of a compound of formula (1): wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, aryl and non-aromatic heterocyclic groups, or each of one or more pair(s) of the substituent groups R1 to R6 may together form a 3, 4, 5, 6, 7 or 8-membered ring containing 0, 1 or 2 heteroatom(s); R7 is selected from alkyl, aryl and non-aromatic heterocyclic groups, and R8 is selected from hydrogen, halogen, alkyl, aryl and non-aromatic heterocyclic groups; and pharmaceutically acceptable salts and prodrugs thereof, in the manufacture of a medicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission; novel compounds of formula (1) per se and for use in therapy.