5-Methyl-3-phenyl-4-([1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-1,2-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-Methyl-3-phenyl-4-([1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-1,2-oxazole
• 化学式: C₂₀H₁₄N₄O
• 分子量: 326.4
• InChiKey: ONOITJXOHKRUOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  56.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] TRIAZOLOPHTHALAZINE / QUINOLINE / ISOQUINOLINE DERIVATIVES WHICH ARE LIGANDS FOR GABA-A RECEPTORS CONTAINING THE ALPHA 5 SUBTYPE<br/>[FR] DERIVES DE TRIAZOLOPHTHALAZINE/QUINOLINE/ISOQUINOLINE QUI SONT DES LIGANDS POUR DES RECEPTEURS GABA-A CONTENANT LE SOUS-TYPE ALPHA 5
  申请人：MERCK SHARP & DOHME

  公开号：WO2002081474A1

  公开（公告）日：2002-10-17

  The present invention provides a compound of formula (I): in which R1 is an aromatic or heteroaromatic ring, M is a bond, -CH¿2?-, -O- or -S-, R?2, R3 and R4¿ are as defined herein, and X, Y and Z generally define a 1,2,4-triazolo[3,4-a]phthalazine, 1,2,3-triazolo[1,5-a]quinoline or 1,2,4-triazolo[3,4-a]isoquinoline core, as a ligand for GABA-A receptors containing the alpha 5 subtype and which is preferably an inverse agonist thereat and is thus useful for enhancing cognition in conditions such as Alzheimer's disease, compositions containing it, its use in therapy, use of it for making medicaments and methods of treatment using it.