N'-(2-aminoethyl)-N'-pentadecylethane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-(2-aminoethyl)-N'-pentadecylethane-1,2-diamine
• 化学式: C₁₉H₄₃N₃
• 分子量: 313.6
• InChiKey: JGFWIGNILMIBMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N'-(2-aminoethyl)-N'-pentadecylethane-1,2-diamine 、 聚合甲醛 、 甲酸 以70%的产率得到
  参考文献：
  名称：

  DEVINSKY, F.;BITTEREROVA, F.;LACKO, I.;MLYNARCIK, D., CHEM. ZVESTI, 1985, 39, N 1, 125-134

  摘要：

  DOI：

文献信息

• COATING COMPOSITION AND MEDICAL DEVICE
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：US20160015864A1

  公开（公告）日：2016-01-21

  A coating composition capable of forming a drug coating layer unsusceptible to peeling in the process of delivery of a water-insoluble drug to a target tissue is provided. The coating composition contains the water-insoluble drug and a basic compound which is positively charged at physiological pH. A medical device coated with the coating composition is further provided.

  提供一种涂层组合物，能够形成一层药物涂层，在向目标组织输送水不溶性药物的过程中不易剥落。该涂层组合物含有水不溶性药物和一种在生理pH下呈正电荷的碱性化合物。此外，还提供了涂有该涂层组合物的医疗器械。
• LIPOSOMES
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP1044679A1

  公开（公告）日：2000-10-18

  This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment of diseases, particularly renal diseases, that accompany production of proteoglycan, comprising (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol% of (1) based on (3) and from 0.2 to 5 mol% of (2) based on the total of (1) and (3).

  本发明提供了一种含有药物的脂质体，该脂质体具有活性靶向性，并确保在血液中的稳定性，可有效用于诊断和/或治疗伴随蛋白多糖产生的疾病，特别是肾脏疾病、包括(1)在生理 pH 值范围内带正电荷的碱性化合物，(2)亲水性聚合物的脂质衍生物和(3)构成脂质体的脂质，作为其膜构成成分，其中它们的构成比例为(1)占(3)的 1 至 20 摩尔%，(2)占(3)的 0.2至5 摩尔%的(2)，以(1)和(3)的总和为基准。
• Liposome
  申请人：Terumo Kabushiki Kaisha

  公开号：US20030211142A1

  公开（公告）日：2003-11-13

  This invention provides a liposome having a drug included therein, which has active targeting property and ensured stability in blood and can be used effectively in the diagnosis and/or treatment of diseases, particularly renal diseases, that accompany production of proteoglycan, comprising (1) a basic compound which takes positive charge within a physiological pH range, (2) a lipid derivative of a hydrophilic polymer and (3) a lipid which constitutes the liposome, as its membrane constituting components, wherein their constituting ratios are from 1 to 20 mol % of (1) based on (3) and from 0.2 to 5 mol % of (2) based on the total of (1) and (3).

  本发明提供了一种含有药物的脂质体，该脂质体具有活性靶向性，并确保在血液中的稳定性，可有效用于诊断和/或治疗伴随蛋白多糖产生的疾病，特别是肾脏疾病、包括(1)在生理 pH 值范围内带正电荷的碱性化合物，(2)亲水性聚合物的脂质衍生物和(3)构成脂质体的脂质，作为其膜构成成分，其中它们的构成比例为：(1)占(3)的 1 至 20 摩尔%，(2)占(3)的 0.以(1)和(3)的总和为基准，(2)的比例为 0.2 至 5 摩尔%。
• Stable Liposomes for Targeted Drug Delivery
  申请人：Terumo Kabushiki Kaisha

  公开号：EP1044679B1

  公开（公告）日：2012-12-26
• US6562371B1
  申请人：——

  公开号：US6562371B1

  公开（公告）日：2003-05-13