N-[3-cyano-1-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidin-3-yl]-2-(cyclohexylmethyl)-4-morpholin-4-yl-4-oxobutanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-[3-cyano-1-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidin-3-yl]-2-(cyclohexylmethyl)-4-morpholin-4-yl-4-oxobutanamide
• 化学式: C₃₀H₄₂N₄O₃
• 分子量: 506.7
• InChiKey: JQYWFKYIMLUEEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel succinate derivative compounds useful as cysteine protease inhibitors
  申请人：——

  公开号：US20010041700A1

  公开（公告）日：2001-11-15

  Disclosed are novel succinate derivative compounds of the formula (I)/(Ia): 1 wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.

  披露了新型琥珀酸衍生物化合物，其化学公式为(I)/(Ia)：1，其中R1、R2、R3、R4、R5、R6、R7、X和A的定义如下。这些化合物可用作胱氨酸蛋白酶的抑制剂。还披露了使用和制造这些化合物的方法。
• NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030087939A1

  公开（公告）日：2003-05-08

  Disclosed are novel succinate derivative compounds of the formula (I)/(Ia): 1 wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.

  本发明公开了一类新型琥珀酸衍生物化合物，其化学式为(I)/(Ia):1，其中R1、R2、R3、R4、R5、R6、R7、X和A的定义如本文所述。这些化合物可用作半胱氨酸蛋白酶的抑制剂。本发明还公开了使用这些化合物的方法和制备这些化合物的方法。
• US6313117B1
  申请人：——

  公开号：US6313117B1

  公开（公告）日：2001-11-06
• US6649642B2
  申请人：——

  公开号：US6649642B2

  公开（公告）日：2003-11-18
• [EN] NOVEL SUCCINATE DERIVATIVE COMPOUNDS USEFUL AS CYSTEINE PROTEASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSES DE DERIVES DE SUCCINATE UTILISES COMME INHIBITEURS DES CYSTEINE PROTEASES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2001009110A1

  公开（公告）日：2001-02-08

  Disclosed are novel succinate derivative compounds of formula (I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.