galtonioside A

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: galtonioside A
• 英文别名: [(1S,2S,4S,6S,7R,8S,9R,10S,12R,13S,14S,15S,17R,19R)-7-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-12,15-dihydroxy-14-(hydroxymethyl)-8,10-dimethyl-6-(2-methylprop-1-enyl)-5-oxapentacyclo[11.8.0.02,10.04,9.014,19]henicosan-17-yl] 3,4,5-trimethoxybenzoate
• 化学式: C₄₈H₇₂O₁₉
• 分子量: 953.088
• InChiKey: KGQCPFLOKMIEPS-KHHGPXSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  67
• 可旋转键数：
  13
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  282
• 氢给体数：
  9
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  galtonioside A 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 (1S,2S,4S,6S,7R,8S,9R,10S,12R,13S,14S,15S,17R,19R)-7-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-14-(hydroxymethyl)-8,10-dimethyl-6-(2-methylprop-1-enyl)-5-oxapentacyclo[11.8.0.02,10.04,9.014,19]henicosane-12,15,17-triol
  参考文献：
  名称：

  Galtonioside A, a novel cytotoxic cholestane glycoside from Galtonia candicans

  摘要：

  A novel polyoxygenated 5 beta-cholestane diglycoside, named galtonioside A, was isolated from the bulbs of Galtonia candicans by way of a cytotoxicity-guided fractionation procedure against HL-60 leukemia cells. Galtonioside A showed differential cytotoxicity in the Jpn. Fdn. for Cancer Res. 38 cell line assay. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02058-4

文献信息

• Galtonioside A, a novel cytotoxic cholestane glycoside from Galtonia candicans
  作者：Minpei Kuroda、Yoshihiro Mimaki、Yutaka Sashida、Takao Yamori、Takashi Tsuruo

  DOI：10.1016/s0040-4039(99)02058-4

  日期：2000.1

  A novel polyoxygenated 5 beta-cholestane diglycoside, named galtonioside A, was isolated from the bulbs of Galtonia candicans by way of a cytotoxicity-guided fractionation procedure against HL-60 leukemia cells. Galtonioside A showed differential cytotoxicity in the Jpn. Fdn. for Cancer Res. 38 cell line assay. (C) 1999 Elsevier Science Ltd. All rights reserved.