N-(1H-indazol-5-yl)-2-(3-methoxyphenyl)quinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(1H-indazol-5-yl)-2-(3-methoxyphenyl)quinazolin-4-amine
• 化学式: C₂₂H₁₇N₅O
• 分子量: 367.4
• InChiKey: VZTBXVQXICJUPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  75.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Rho-kinase inhibitors
  申请人：Nagarathnam Dhanaphalan

  公开号：US20060142313A1

  公开（公告）日：2006-06-29

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明涉及化合物及其衍生物、其合成和作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症（例如冠心病）非常有用。
• RHO-KINASE INHIBITORS
  申请人：Nagarathnam Dhanaphalan

  公开号：US20100137324A1

  公开（公告）日：2010-06-03

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明揭示了化合物及其衍生物，它们的合成以及它们作为Rho-激酶抑制剂的用途。本发明的这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症，例如冠心病，是有用的。
• COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION
  申请人：ROSCIGNO Robert

  公开号：US20090036465A1

  公开（公告）日：2009-02-05

  Methods for treatment of pulmonary hypertension include administration of a first amount of treprostinil and administration of a second amount of a Rho kinase inhibitor such that the first amount and the second amount form together an amount effective for pulmonary hypertension treatment. Kits for treatment pulmonary hypertension are also disclosed.
• [EN] RHO-KINASE INHIBITORS<br/>[FR] INHIBITEURS DE RHO-KINASE
  申请人：BAYER AG

  公开号：WO2002076976A2

  公开（公告）日：2002-10-03

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
• [EN] COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION<br/>[FR] Thérapie de combinaison pour l'hypertension artérielle pulmonaire
  申请人：UNITED THERAPEUTICS CORP

  公开号：WO2008049000A2

  公开（公告）日：2008-04-24

  [EN] Methods for treatment of pulmonary hypertension include administration of a first amount of treprostinil and administration of a second amount of a Rho kinase inhibitor such that the first amount and the second amount form together an amount effective for pulmonary hypertension treatment. Kits for treatment pulmonary hypertension are also disclosed.
  [FR] La présente invention concerne des procédés de traitement de l'hypertension pulmonaire. Lesdits procédés incluent l'administration d'une première quantité de tréprostinil et l'administration d'une seconde quantité d'un inhibiteur de la kinase Rho, de telle sorte que la première quantité et la seconde quantité forment ensemble une quantité efficace pour le traitement de l'hypertension pulmonaire. La présente invention concerne également des kits pour le traitement de l'hypertension artérielle pulmonaire.