N-(4-chlorobenzyl)-4-hydroxy-6-(3-hydroxy-1-propynyl)-3-isoquinolinecarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(4-chlorobenzyl)-4-hydroxy-6-(3-hydroxy-1-propynyl)-3-isoquinolinecarboxamide
• 英文别名: N-[(4-chlorophenyl)methyl]-4-hydroxy-6-(3-hydroxyprop-1-ynyl)isoquinoline-3-carboxamide
• 化学式: C₂₀H₁₅ClN₂O₃
• 分子量: 366.804
• InChiKey: BCKQEJUCKIHFPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  82.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Heterocycle carboxamides as antiviral agents
  申请人：Pharmacia & Upjohn Company

  公开号：US20020019397A1

  公开（公告）日：2002-02-14

  The present invention provides a compound of formula I 1 which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种I1式化合物，其作为抗病毒剂具有用处，特别是作为针对疱疹家族病毒的药物。
• Method of preventing or treating atherosclerosis or restenosis
  申请人：——

  公开号：US20040176366A1

  公开（公告）日：2004-09-09

  The present invention provides a method of preventing or treating atherosclerosis or restenosis in mammals, which comprises administering an effective amount of a compound selected from the group consisting of structures of Formulas X and XII-XV: 1 wherein the substituent groups are as defined herein.

  本发明提供了一种预防或治疗哺乳动物动脉粥样硬化或再狭窄的方法，该方法包括施用有效量的选自由式X和XII-XV结构组成的组的化合物： 1 其中取代基团如本文所定义。
• HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1363907A2

  公开（公告）日：2003-11-26
• US6730682B2
  申请人：——

  公开号：US6730682B2

  公开（公告）日：2004-05-04
• [EN] HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS<br/>[FR] CARBOXAMIDES HETEROCYCLIQUES UTILISES COMME AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2002004443A2

  公开（公告）日：2002-01-17

  The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.