[1-acetyloxy-1-(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)propan-2-yl] acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: [1-acetyloxy-1-(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)propan-2-yl] acetate
• 化学式: C₁₃H₁₉N₅O₅
• 分子量: 325.32
• InChiKey: CAERRKGTXCZMPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  144
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Use of bh4 for the treatment of respiratory diseases
  申请人：Hesslinger Christian

  公开号：US20070049599A1

  公开（公告）日：2007-03-01

  The invention describes the use of Tetrahydrobiopterin (BH4) or derivatives thereof for the treatment of COPD. In a preferred embodiment, BH4 or derivates thereof are combined with arginine or derivatives thereof.
• Combination of a Pd4 Inhibitor and a Tetrahydrobiopterin Derivative
  申请人：Hesslinger Christian

  公开号：US20080221111A1

  公开（公告）日：2008-09-11

  The invention describes the use of a PDE4 inhibitor in combination with BH4 or a BH4 derivative for the prevention and/or treatment of respiratory diseases.
• Use of Tetrahydrobiopterine Derivatives in the Treatment and Nutrition of Patients With Amino Acid Metabolic Disorders
  申请人：BioMarin Pharmaceutical Inc.

  公开号：US20170042899A1

  公开（公告）日：2017-02-16

  The invention relates to the use of tetrahydrobiopterine and the derivatives thereof in the production of a medicament to improve protein tolerance for the treatment of diseases arising from an amino acid metabolic disorder, e.g. hyperphenylalaninemia. The invention also relates to a composition which contains tetrahydrobiopterine or derivatives thereof in addition to a special mixture of amino acids. The invention can, for instance, be used as a food which is low in phenylalanine in the complete nutrition of hyperphenylalaninemic patients. Tests carried out within the text of said invention revealed that by treating the context of said invention revealed that by treating patients who had phenylalanine concentrations of more than 200 μmol/l in their blood with tetrahydrobiopterine, it was possible to reduce the concentrations of phenylalanine by 37% to 92%.
• US7820667B2
  申请人：——

  公开号：US7820667B2

  公开（公告）日：2010-10-26
• [EN] USE OF BH4 FOR THE TREATMENT OF RESPIRATORY DISEASES<br/>[FR] UTILISATION DE LA BH4 DANS LE TRAITEMENT DES MALADIES RESPIRATOIRES
  申请人：ALTANA PHARMA AG

  公开号：WO2005041975A1

  公开（公告）日：2005-05-12

  The invention describes the use of Tetrahydrobiopterin (BH4) or derivatives thereof for the treatment of COPD. In a preferred embodiment, BH4 or derivatives thereof are combined with arginine or derivatives thereof.