6-{trans-4-[2-(4-fluorophenoxy)ethylamino]cyclohexyl}-3H-benzoxazol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 6-{trans-4-[2-(4-fluorophenoxy)ethylamino]cyclohexyl}-3H-benzoxazol-2-one
• 英文别名: 6-[4-[2-(4-fluorophenoxy)ethylamino]cyclohexyl]-3H-1,3-benzoxazol-2-one
• 化学式: C₂₁H₂₃FN₂O₃
• 分子量: 370.424
• InChiKey: OPUIZRUSZASMNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Bicyclic cyclohexylamines and their use as nmda receptor antagonists
  申请人：——

  公开号：US20030236252A1

  公开（公告）日：2003-12-25

  Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's specification. disease. The substituents are defined in the specification. 1

  描述了公式（I）的自行车替代环己胺及其药用盐。这些化合物是NMDA受体通道复合物的拮抗剂，可用于治疗脑血管疾病，例如脑缺血、心脏骤停、中风和帕金森病。这些取代基在规范中有定义。
• BICLYCLIC CYCLOHEXYLAMINES AND THEIR USE AS NMDA RECEPTOR ANTAGONISTS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1286975A1

  公开（公告）日：2003-03-05
• US6794402B2
  申请人：——

  公开号：US6794402B2

  公开（公告）日：2004-09-21
• [EN] BICICLIC CYCLOHEXYLAMINES AND THEIR USE AS NMDA RECEPTOR ANTOGONISTS<br/>[FR] CYCLOHEXYLAMINES BICYCLIQUES ET LEUR UTILISATION COMME ANTAGONISTES DU RECEPTEUR DE NMDA (N-METHYL-D-ASPARTATE)
  申请人：WARNER LAMBERT CO

  公开号：WO2001092239A1

  公开（公告）日：2001-12-06

  Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's disease. The substituents are defined in the specification.