4-[(E)-2-diethoxyphosphoryl-2-pyridin-3-ylethenyl]-2-methoxy-6-methylphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[(E)-2-diethoxyphosphoryl-2-pyridin-3-ylethenyl]-2-methoxy-6-methylphenol
• 化学式: C₁₉H₂₄NO₅P
• 分子量: 377.4
• InChiKey: DRQUKKOEWQWKLQ-LDADJPATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  77.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Alpha-substituted heteroarylalkyl phosphonate derivatives
  申请人：Phan Trung Hieu

  公开号：US20050124581A1

  公开（公告）日：2005-06-09

  The present invention relates to novel α-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

  本发明涉及新型的α-取代杂环烷基膦酸酯衍生物及其用于降低血浆apo（a）、Lp（a）、apo B、apo B相关脂蛋白（低密度脂蛋白和超低密度脂蛋白）和降低总胆固醇血浆水平的用途。
• ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES
  申请人：Ilex Products, Inc.

  公开号：EP1482953A1

  公开（公告）日：2004-12-08
• EP1482953A4
  申请人：——

  公开号：EP1482953A4

  公开（公告）日：2006-12-13
• [EN] ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES<br/>[FR] DERIVES ALPHA-SUBSTITUES D'HETEROARYLALKYL PHOSPHONATE
  申请人：ILEX PRODUCTS INC

  公开号：WO2003068240A1

  公开（公告）日：2003-08-21

  The present invention relates to novel α-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.