3(S)-(Quinolin-3-yl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-imidazolidin-1-yl}-propionic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3(S)-(Quinolin-3-yl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-imidazolidin-1-yl}-propionic acid
• 英文别名: 3-(Quinolin-3-yl)-3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-imidazolidin-1-yl}-propionic acid；3-[2-Oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazolidin-1-yl]-3-quinolin-3-ylpropanoic acid
• 化学式: C₂₆H₂₉N₅O₃
• 分子量: 459.548
• InChiKey: QEWQOOZNSGQCPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  98.7
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Treatment of inflammation with a combination of a cyclooxygenase-2 inhibitor and an integrin alpha-v antagonist
  申请人：——

  公开号：US20020040039A1

  公开（公告）日：2002-04-04

  The present invention provides for methods for treating or preventing an inflammatory disease or condition in a mammalian patient in need of such treatment comprising administering to said patient a cyclooxygenase-2 specific inhibitor in combination with an &agr; V &bgr; 3 , &agr; V &bgr; 5 and/or &agr; V &bgr; 6 integrin receptor antagonist in an amount effective to treat or prevent the inflammatory disease or condition. The present invention also provides for pharmaceutical compositions for the treatment or prevention of an inflammatory disease or condition. Further, the invention provides for the manufacture of a medicament useful in the treatment or prevention of an inflammatory disease or condition.

  本发明提供了在需要治疗的哺乳动物患者中治疗或预防炎症性疾病或病症的方法，包括给所述患者施用环氧化酶-2 特异性抑制剂，该抑制剂与 &agr； V &bgr； 3 , &agr； V &bgr； 5 和/或 &agr； V &bgr； 6 整合素受体拮抗剂，其用量对治疗或预防炎症性疾病或病症有效。本发明还提供了用于治疗或预防炎症性疾病或病症的药物组合物。此外，本发明还提供了一种用于治疗或预防炎症性疾病或病症的药物的制造方法。
• Methods and compositions for treating peridontal disease
  申请人：——

  公开号：US20040053968A1

  公开（公告）日：2004-03-18

  The present invention provides for a method for the treatment of alveolar bone loss due to periodontal disease in a subject in need of such treatment comprising administration of a therapeutically effective amount of an &agr;v&bgr;3 integrin receptor antagonist in combination with a therapeutically effective amount of a COX-2 inhibitor. Further, the present invention provides for pharmaceutical compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for treating the alveolar bone loss due to periodontal disease.

  本发明提供了一种治疗需要这种治疗的受试者因牙周病引起的牙槽骨缺损的方法，该方法包括施用治疗有效量的&agr;v&bgr;3整合素受体拮抗剂与治疗有效量的COX-2抑制剂。此外，本发明还提供了在本发明方法中有用的药物组合物，以及一种用于治疗牙周病引起的牙槽骨丧失的药物的制造方法。
• INTEGRIN RECEPTOR ANTAGONISTS
  申请人：MERCK & CO., INC.

  公开号：EP1040111A1

  公开（公告）日：2000-10-04
• TREATMENT OF INFLAMMATION WITH A COMBINATION OF A CYCLOOXYGENASE-2 INHIBITOR AND AN INTEGRIN ALPHA-V ANTAGONIST
  申请人：Merck & Co., Inc.

  公开号：EP1322311A1

  公开（公告）日：2003-07-02
• METHODS AND COMPOSITIONS FOR TREATING PERIODONTAL DISEASE
  申请人：Merck & Co., Inc.

  公开号：EP1349548A2

  公开（公告）日：2003-10-08