N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
• 化学式: C42H48ClFN4O5
• 分子量: 743.3
• InChiKey: OTEMRCVEYVKQCN-SDGIEUFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.31
• 重原子数：
  53
• 可旋转键数：
  8
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] MEMBRANE ENCAPSULATED NANOPARTICLES AND METHOD OF USE<br/>[FR] NANOPARTICULES ENCAPSULÉES DANS UNE MEMBRANE ET LEUR PROCÉDÉ D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2013052167A2

  公开（公告）日：2013-04-11

  Provided are nanoparticles, method of using and making thereof. The invention nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. The present invention further provides immunogenic compositions comprising the inventive nanoparticles, and methods of use the inventive immunogenic compositions for eliciting an immune response and for treating or preventing disease or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles of the present invention are also provided.