5-(phenoxazine-10-carbonyl)-1H-pyridin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 5-(phenoxazine-10-carbonyl)-1H-pyridin-2-one
• 化学式: C₁₈H₁₂N₂O₃
• 分子量: 304.3
• InChiKey: GTQJCSLLRMEANG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel pyridones and their use as modulators of serine hydrolase enzymes
  申请人：Dalhousie University

  公开号：US20020049330A1

  公开（公告）日：2002-04-25

  This invention relates to a compound of formula I: 1 or a pharmaceutically acceptable salt thereof; in which preferably R 3 , R 4 and R 6 are each hydrogen; X is C═O or CH 2 ; and R 7 and R 8 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, (C 3 -C 8 )cycloalkyl and (C 1 -C 2 )alkyl(C 6 -C 14 )aryl; or R 7 and R 8 when taken together form a (C 2 -C 7 )alkylene group; or —NR 7 R 8 together forms a (C 2 -C 14 )heterocyclic or substituted (C 2 -C 14 )heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.

  这项发明涉及一种化合物，其化学式为I:1或其药用盐；其中，最好的情况是R3、R4和R6分别为氢；X为C═O或CH2；而R7和R8分别独立地选自氢、(C1-C12)烷基、(C3-C8)环烷基和(C1-C2)(C6-C14)芳基的组合；或者当R7和R8一起形成(C2-C7)烷基基团时；或者—NR7R8一起形成(C2-C14)杂环或取代的(C2-C14)杂环。这些化合物调节丝氨酰水解酶的活性，可用于治疗阿尔茨海默病的药物组合物中。
• US6436972B1
  申请人：——

  公开号：US6436972B1

  公开（公告）日：2002-08-20
• US6544986B2
  申请人：——

  公开号：US6544986B2

  公开（公告）日：2003-04-08
• [EN] NOVEL PYRIDONES AND THEIR USE AS MODULATORS OF SERINE HYDROLASE ENZYMES<br/>[FR] NOUVELLES PYRIDONES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE SERINE-HYDROLASES
  申请人：UNIV DALHOUSIE

  公开号：WO2001077078A1

  公开（公告）日：2001-10-18

  This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; in which preferably R?3, R4 and R6¿ are each hydrogen; X is C=0 or CH¿2?; and R?7 and R8¿ are each independently selected from the group consisting of hydrogen, (C¿1?-C12)alkyl, (C3-C8)cycloalkyl and (C1-C12)alkyl(C6-C14)aryl; or R?7 and R8¿ when taken together form a (C¿2?-C7)alkylene group; or -NR?7R8¿ together forms a (C¿2?-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.