[3-(11-chloro-1H-8-oxa-1-aza-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-dimethyl-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: [3-(11-chloro-1H-8-oxa-1-aza-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-dimethyl-amine
• 英文别名: 3-[(17-chloro-13-oxa-3-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),2(6),4,7,9,11,15,17-octaen-4-yl)methoxy]-N,N-dimethylpropan-1-amine
• 化学式: C₂₂H₂₃ClN₂O₂
• 分子量: 382.89
• InChiKey: OZMAVXRTPXTMBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
  申请人：Mercep Mladen

  公开号：US20050148578A1

  公开（公告）日：2005-07-07

  The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1-aza-二苯并蓝衍生物，其药理学上可接受的盐和溶剂，制备过程和中间体，以及它们的抗炎作用，特别是抑制肿瘤坏死因子-α（TNF-α）的产生和抑制白细胞介素-1（IL-1）的产生，以及它们的镇痛作用。
• 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
  申请人：Mercep Mladen

  公开号：US20050209191A1

  公开（公告）日：2005-09-22

  The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及 1-aza-dibenzoazulene 衍生物、其药理学上可接受的盐类和溶剂、制备它们的工艺和中间体，以及它们的抗炎作用，特别是抑制肿瘤坏死因子-α (TNF-α) 的产生和抑制白细胞介素-1 (IL-1) 的产生，以及它们的镇痛作用。
• 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1506202B1

  公开（公告）日：2007-08-08
• 1-Aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders
  申请人：Mercep Mladen

  公开号：US20070111968A1

  公开（公告）日：2007-05-17

  The present invention relates to the use of compounds from the group of 1-aza-dibenzo[e,h]azulenes and of their pharmacologically acceptable salts and solvates in a pharmaceutical formulation for the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.
• US7312203B2
  申请人：——

  公开号：US7312203B2

  公开（公告）日：2007-12-25